◆On-Demand Webinar Distribution◆ A Ray of Hope for Challenges in LNP Research and Development

Unchained Labs (アンチェインドラブズ）

The development of lipid nanoparticles (LNP) requires flexible tools that can accommodate everything from screening to GMP manufacturing. The ideal manufacturing equipment should be capable of handling a wide range of applications, from small-scale, easy-to-handle experiments to multi-parameter, multi-sample, large-scale continuous operations. Additionally, not only is the production of LNP important, but the evaluation of characteristics such as encapsulation efficiency (EE%), RNA amount, particle size, and PDI is also crucial; traditionally, these measurements have been complicated and required multiple instruments. In this webinar, we will introduce scalable LNP manufacturing by Sunshine and one-stop measurements of EE%, total RNA, particle size, PDI, and particle concentration using Stunner AF. Furthermore, you will also be able to watch a demo video showcasing the actual operation of the Sun series (Sunshine, Sunscreen) and Stunner! Instructor: Takuma Iwasaki | Field Application Scientist *This webinar is a recording of a session hosted by Unchained Labs, Inc. in October 2025.

Date and time Thursday, Dec 18, 2025 ～ Friday, Jan 30, 2026
Capital
Entry fee Free

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Protein and Nucleic Acid Quality Evaluation Device 'STUNNER'
Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

【Specifications (Excerpt)】 ■Dimensions: Width 37 cm, Depth 54 cm, Height 33 cm, Weight 26 kg ■Electrical Characteristics: Universal input voltage 100–240 V AC, 50–60 Hz ■Computer: Separate computer with Windows 10 ■Connection: USB, TCP/IP (Service) ■Approvals: CE, FCC, CSA ■Regulatory Compliance: Optional 21 CFR Part 11 software package *For more details, please refer to the PDF document or feel free to contact us.
Lipid nanoparticle automatic synthesis system Sunshine
Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Throughput: 10 samples in 15 minutes Total flow rate range: 0.1 to 30 mL/min (depending on the chip) Flow ratio (water to organic) range: 1:1 to 10:1 Standard sample volume range (when FRR is 3:1): 1 to 6.5 mL Minimum input volume (including dead volume): 320 μL Continuous mode capacity range: 20 mL to infinity in continuous mode Inline dilution: Yes Standard particle size range: 40 to 200 nm* PDI: Less than 0.2* Encapsulation efficiency: Over 90%*
Automatic Synthesis and Screening System for Lipid Nanoparticles Sunscreen
Accelerating formulation optimization for vaccine and pharmaceutical development.

Throughput: Up to 96 formulations within 6 hours Total flow range: 0.1 to 30 mL/min (depending on the tip) Flow ratio (water to organic): 1:1 to 5:1 Standard sample volume range (when FRR is 3:1): 400 µL to 2 mL Minimum input volume (including dead volume): 105 µL Continuous mode capacity range: NA Inline dilution: Yes Standard particle size range: 40 to 200 nm (depending on the formulation) PDI: Less than 0.2 (depending on the formulation) Encapsulation efficiency: Over 90% (depending on the formulation)
GMP-compliant lipid nanoparticle automatic synthesis system Sunbather
Accelerating formulation optimization for vaccine and pharmaceutical development.

Throughput: 10 mL/min per channel Total flow rate range: 0.1 to 30 mL/min (depending on configuration) Flow ratio (water to organic) range: 1:1 to 10:1 Standard sample volume range (when FRR is 3:1): 400 µL to 2 mL Inline dilution: Yes Standard particle size range: 40 to 200 nm (depending on formulation) PDI: Less than 0.2 (depending on formulation) Encapsulation efficiency: Over 90% (depending on formulation)

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Benefits of LNP Automated Process Optimization Using Sunshine - Columbia University Case Study

TECHNICAL

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