In recent years, with the advancement and enhancement of polymer materials, various additives for synthetic polymers with different functions have been used in optimized formulations. Among them, there are types of additives, such as hindered amine light stabilizers (HALS) and lubricants, that present challenges in solubility and detection methods, making analysis difficult. Additionally, when conducting structural analysis of multi-component polymers or terminal group analysis using pyrolysis gas chromatography-mass spectrometry (PyGC/MS), there are many pyrolysis products not registered in the EI method database, making analysis not straightforward. In this webinar, we will introduce two solutions to the challenges in the characterization of synthetic resins, along with practical examples. ■ Overview of additives for synthetic polymers ■ Actual quantitative analysis of HALS/lubricants ■ Examples of structural analysis of synthetic resins using PyGC/Q-Tof MS Target audience: Individuals handling organic compounds for the development and quality control of materials and industrial products.

Waters has developed the robust single quadrupole mass spectrometer RADIAN ASAP, equipped with the atmospheric pressure solid sample analysis probe (ASAP) ionization method, specifically designed for rapid, easy, and low-cost analysis of liquids and solids. It can directly ionize samples from liquids or solids, making it suitable for a wide range of applications and workflows. With excellent flexibility, operability, and speed, the RADIAN ASAP does not require complex sample pretreatment, separation, or analytical experience, helping you achieve more results. The multivariate analysis-capable LiveID software allows for real-time classification of samples analyzed with the RADIAN ASAP. Analytical results are immediately provided to the user, enabling instant decision-making based on the analytical information. In this webinar, we will first cover the basics of mass spectrometry, followed by an introduction to the principles, usage, features, and actual analysis cases of the RADIAN ASAP. Program: ■ Overview of mass spectrometry ■ Overview, usage, and features of RADIAN ASAP ■ Analysis cases in pharmaceuticals, chemistry, food, and forensics

Waters provides total solutions to support customers from sample preparation in food analysis and separation by high-performance liquid chromatography to mass spectrometry. In this webinar, we will introduce the basics of sample preparation methods, including examples of positive list simultaneous analysis, as well as analysis examples using LC/MS/MS. We will also showcase the latest Waters sample preparation equipment, such as the pressure-controlled manifold (Otto SPEcialist pressure manifold) and automatic liquid handling (Andrew Alliance). Program: ■ The necessity of sample preparation ■ Examples of food analysis applications using solid-phase extraction and QuEChERS methods ■ Introduction of the latest Waters sample preparation equipment - Otto SPEcialist pressure manifold - Waters amino acid analysis method and automatic liquid handling

Waters provides total solutions to support customers from sample preparation in food analysis to separation by high-performance liquid chromatography and mass spectrometry. In this context, we will introduce a simple and reliable high-speed amino acid analysis method (AccQ-Tag amino acid analysis method), which is important for food component analysis. We will also provide information on new products, such as the new mixed-mode column (Atlantis PREMIER BEH C18 AX Columns) that enables the high-speed analysis of 15 organic acids, as well as column selection for efficiently conducting various analyses, using examples like vitamins and sugars. Program: ■ About the amino acid analysis method (AccQ-Tag amino acid analysis method) ■ Column selection for food component analysis ■ Introduction of the latest columns

An explanation of the causes of tailing of ionic substances in the analysis of reverse phase systems and the selection of mobile phases for improvement.

This explains how to set separation conditions with a focus on the most commonly used reverse phase. It mainly describes the approach from the mobile phase side regarding how to effectively progress with condition setting.

This article discusses the issue of ionic substances not being retained in the analysis of reverse phase systems, along with the causes and methods for improvement (ion suppression chromatography and ion-pair chromatography).

What is mass spectrometry? An explanation of the types and principles of ionization methods, as well as considerations for LC conditions.

Introduction to the types of mobile phases used in LC/MS, matrix effects, and changes in sensitivity due to mobile phase considerations.

I can't see the peak! When such a phenomenon occurs, we will conduct an investigation to determine the cause. In this webinar, we will introduce a step-by-step method for verification.

An overview of GPC (SEC/GFC) used in polymer analysis and key points for basic analysis will be explained.

Introducing an information processing tool that supports HDMS(E) data and effectively utilizes the advantages of maximized peak capacity through ion mobility separation in a powerful and efficient new workflow.

A webinar discussing the necessary considerations, issues, and solutions in the development of analytical methods for ion exchange and size exclusion chromatography. The content is applicable not only to biopharmaceuticals but also to the analysis of other proteins.

This discusses the issues revealed by the results of a blind test for protein identification conducted by multiple facilities, and what is necessary to achieve comprehensive and reliable identification.

The key to solving problems lies in identifying the cause. This explains methods for quickly and reliably finding the cause, focusing on solid-phase extraction.

Introducing the efficiency of reverse phase analysis of intact proteins, as well as the issues of quantitative analysis using reverse phase and the methods for developing analytical techniques.

A clear explanation of the key points of column technology and system design to maximize the performance of particles with a diameter of 2 μm or less, achieving the separation and speed predicted by theory (UPLC separation).

"Smart MS" BioAccord System Latest Information Webinar We will hold a WEB seminar (on-demand) introducing the product overview of the BioAccord LC-MS system, which supports routine analysis of biopharmaceuticals, peptide drugs, and nucleic acid drugs. Additionally, we will explain the Multi Attribute Method (MAM), analysis of nucleic acid drugs, and new applications for adeno-associated viruses (AAV).

Introducing UPLC and columns specifically for glycan separation, multifunctional mass spectrometers, and glycan analysis using informatics.

We will introduce how to deal with a carryover situation and how to identify the causes and solutions when a ghost peak is observed.

From the perspective of retaining polar compounds, we will introduce the utilization of reverse phase and HILIC modes in the food and environmental fields, along with key points for selecting useful columns.

This is an easy-to-understand introduction for those who need sample preprocessing, explaining its necessity and how to choose the most suitable preprocessing method for their analysis.

The molecular weight distribution and additives of polymer materials are significant factors that greatly contribute to the physical properties and lifespan of the materials, making them widely analyzed from material development to quality control. Typically, these two analyses employ different separation modes, requiring dedicated systems and separate pretreatment methods. However, efficiency can be improved by conducting both analyses in a single analysis using the same pretreatment sample. In this webinar, you will learn about the new technology of GPC/MS and the application of simultaneous measurement of molecular weight distribution and additive quantification. Main content of the webinar: ■ Principles and advantages of high-resolution GPC ■ How to utilize GPC + RI detector + MS detector ■ Simultaneous analysis methods and approaches for molecular weight distribution and additive quantification Target audience: ■ Those using GPC systems ■ Those using LC, LC/MS, and GC/MS for additive analysis ■ Individuals involved in research and development, quality assurance, and management of polymer materials Program: ■ Measurement of molecular weight distribution and additive quantification in polymer materials ■ Principles and characteristics of high-resolution GPC ■ Challenges in GPC/MS systems and analysis ■ Case studies of simultaneous analysis of molecular weight distribution and additives

Please explain what chromatography is, what types of stationary and mobile phases are used in liquid chromatography (LC), and what kinds of separation modes exist in LC.

CPhI Webinars: "COVID-19" Vaccine & Therapeutics Research and Development Webinar Waters held an LC/MS Webinar related to the novel coronavirus at CPhI Webinars 2020 (organized by Informa Markets Japan Co., Ltd.). Thank you to everyone who participated. The on-demand version is now available, so please take a look. [Title] "Latest LC/MS Technology Information Accelerating Novel Coronavirus Research" [Abstract] Among the analytical techniques supporting research on therapeutics and vaccine development for COVID-19, liquid chromatography-mass spectrometry (LC/MS) is at the core of separation analysis. Here, we will introduce the latest analytical techniques and case studies targeting proteins, lipids, glycans, nucleic acids, and more.

When assessing the safety and efficacy of pharmaceuticals, the quality and robustness of analytical data are extremely important. The currently discussed ICH guidelines are considering a lifecycle approach to improve the consistency and robustness of analytical method quality over the long term. By deploying the developed analytical methods to quality control labs using the latest HPLC, it is possible to reduce OOS (Out of Specification) and OOT (Out of Trend) occurrences. In this webinar, we will explain the challenges of routine analysis in quality control labs and their solutions. We will also introduce a new product, Arc HPLC, which allows for a smooth transfer of existing LC analytical methods and enables the acquisition of higher quality data.

Compounds or their metabolites found in pharmaceuticals, cosmetics, and food can have high hydrophilicity. In environmental monitoring, hydrophilic and highly polar compounds may also be targeted in water system environmental analysis. Since these compounds are difficult to analyze using conventional reverse phase chromatography, hydrophilic interaction chromatography (HILIC) is often suitable. On the other hand, many people may think, "It sounds complicated just by the name," and have not yet tried HILIC, or they may not be satisfied with their current HILIC analysis. In this seminar, we will introduce the principles of HILIC analysis, key points for method development, and columns suitable for HILIC analysis. Program: ■ Basics of HILIC mode ■ Development of HILIC analytical methods ■ Columns suitable for HILIC mode and analysis examples Target Audience: ■ Those analyzing highly polar and hydrophilic compounds ■ Those planning to conduct analyses in the future ■ Those considering improvements to their current HILIC analysis

In this live webinar, we will have a presentation from Shionogi Pharma on the high-sensitivity analysis of nitrosamine impurities. ■Target Audience Those developing impurity analysis methods and those involved in quality control analysis.

A clear explanation with examples on how to verify whether the LC system is performing at its intended capacity.

Have you ever struggled with scaling up from analytical to preparative chromatography? Many people may be facing issues such as the chromatogram examined in the analysis not being reproducible, excessive solvent consumption, or a short lifespan of the preparative column. In this seminar, we will explain tips for preparative purification to maximize the load and obtain as many target substances as possible in a single purification, using analytical examples. Program: ■ Workflow of preparative purification ■ How to determine preparative conditions ■ Tips for selecting preparative columns ■ Introduction of examples of preparative purification