We are currently holding a nitrosamine analysis observation event year-round at our Tokyo headquarters and Osaka branch showrooms. After confirming your preferred date, we will adjust the schedule and generally guide one group per day. Please send the following necessary information via the inquiry form on this page to apply: ■ Preferred venue (Tokyo or Osaka) ■ Preferred date - First choice ■ Preferred date - Second choice ■ Expected number of participants (up to 5 people) ■ Other requests By clicking [Send], you are deemed to have agreed to Waters' use and processing of the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

Xevo TQ Absolute is a robust LC-MS/MS that allows for easy quantification of challenging compounds with absolute sensitivity and reliability. ■ Application Notes Please contact us if you are interested. - High-sensitivity bioanalysis of low molecular weight pharmaceuticals - Bioanalysis of oligonucleotide drugs - High-sensitivity analysis of mutagenic boronic acids - Analysis of free testosterone in serum - Quantification of N-nitrosamines - Analysis of carboxy-THC in hair - Analysis of drugs in blood for toxicological investigations - Speciation analysis of gelatin - Analysis of anionic polar pesticides in food - Measurement of glyphosate, aminomethylphosphonic acid (AMPA), and glufosinate in drinking water - Measurement of chlorates, perchlorates, and bromates in food - Analysis of PFAS (method development and evaluation, in drinking water, aqueous matrices, soil and tissue, vegetables, fruits, baby food, animal products, etc.)

No compromise on performance or speed, the cutting-edge QTof Xevo MRT mass spectrometer ■ Brochures and Application Notes Please contact us if you wish to receive them. (Some materials are available in English only) - High-throughput lipidomics workflow using Xevo MRT - Improved throughput while maintaining the reliability of lipidomics identification results with ballistic gradient, vacuum-jacketed columns, and MRT - Screening of extracellular vesicle metabolomics using Xevo MRT - Exploratory lipidomics testing for colorectal cancer using Xevo MRT mass spectrometer and Lipostar data analysis workflow product solutions - Mapping of phosphorylation of peptide biomarkers corresponding to glioblastoma using DDA and Xevo MRT - High-sensitivity high-throughput LC-MS analysis of eicosanoids using Xevo MRT - Feasibility of single-cell lipidomics using Xevo MRT - Metabolomics workflow using Xevo MRT

We will introduce the principles of the data acquisition mode LC/MSE, which allows for the acquisition of precursor ion and product ion information for all peaks, as well as the principles of ion mobility and the application of these technologies to shotgun proteomics.

In the development of antibody drugs, analyzing the interaction between antigen proteins and antibodies is very important. This time, we will introduce epitope analysis that examines the binding sites of antigen proteins to antibodies using HDXMS with mass spectrometry.

We will introduce an overview and representative application examples of a new system solution that expands the possibilities of separation for samples that are difficult to separate, have low volatility, or undergo thermal degradation, which are challenges faced by conventional technologies such as LC and GC.

Introducing the procedure for creating new LC/MS analysis conditions.

Introducing key points for mobile phase preparation to achieve good results in LC.

We present a video on how to connect columns using stainless steel ferrules, screws, and PEEK integrated hand-tight fittings. Supplementary materials, including product numbers for the connection components, are available for download.

We will introduce the analysis and structural analysis of organic fluorine materials. Here, you can see a variety of approaches equipped with attachments such as a high-resolution mass spectrometer, a ring-shaped ion mobility cell, direct probes, and imaging. The keyword "organic fluorine materials" imparts unique properties to compounds due to the size and electronegativity of the atoms, but it also has the troublesome aspect of being difficult to analyze by mass spectrometry due to the absence of isotopes. Don't miss the opportunity to participate in this spicy webinar that skillfully tackles these fluorines. Program: ■ Features and overview of cIMS ■ Introduction of ion source options for material sample analysis ■ Examples of structural analysis of organic fluorine compounds Target Audience: Individuals using precision mass spectrometry in various fields such as pesticides, pharmaceuticals, and chemical industry.

Due to the diversification and complexity of analysis targets, as well as changes in modalities, HPLC is required to have a higher level of robustness, reproducibility, flexibility, and convenience. Particularly in the analysis of compounds that are susceptible to metal influences, unpredictable sample loss can sometimes occur, making rapid and accurate data analysis difficult and potentially impairing operational efficiency. In this live webinar, we will introduce cases where the analysis results of samples that tend to adsorb metals have significantly improved by using the newly designed Arc Premier HPLC system and Premier columns, which reduce sample adsorption. By avoiding various risks associated with measuring adsorbent samples and improving data quality, we promote increased sample throughput, reduced analysis costs, and enhanced laboratory operational efficiency. Target Audience: - Those struggling with the measurement of samples that tend to adsorb metals - Those looking for low-adsorption LC systems and columns

Explanation of the causes and countermeasures for LC column degradation.

Introducing a video on how to cut stainless steel tubes and PEEK tubes. Supplementary materials such as product numbers for tube cutters are available for download.

Here are some measures to take when the LC pressure is lower than usual.

Here are some measures to take when the pressure of the LC is higher than usual.

Here is how to handle cases where carryover or ghost peaks are detected in LC.

Introducing how to handle issues that arise with the LC baseline.

Column? Sample? Or device? ... First, we will explain a troubleshooting strategy to efficiently identify the cause and solve problems in LC analysis.

If the reproducibility of the response (area) is poor, accurate quantitative results cannot be obtained. This webinar will explain how to identify the causes of poor reproducibility and how to address them.

In this seminar, we will introduce case studies of analytical method development using QbD software: Fusion, and present solutions that are helpful for developing robust analytical methods. ◆ Development of testing methods using the analytical method and method development software Fusion Dr. Taiki Kamiya, Kaken Pharmaceutical Co., Ltd. The analysis department of the CMC Center, to which the speaker belongs, has been developing testing methods using HPLC and introduced Fusion four years ago to improve operational efficiency. This time, we will explain the introduction environment, background, and overview of Fusion, and introduce the operational methods used in the department. Additionally, we will share impressions of using Fusion (advantages and challenges) as well as examples of testing method development (successes and failures). ◆ Waters Analytical Development Solutions, Waters Japan We will introduce mass spectrometers that can be used in conjunction with QbD software, LC systems that enable smooth development and transfer of analytical methods, and the quality of analytical columns, which is crucial for conducting robust analyses over the long term.

Waters provides numerous innovative technologies to leading companies in the global cosmetics and personal care products industry to improve the efficiency of inspections related to raw materials, ingredients, safety, and quality control. By leveraging our continuously advancing sample preparation products, columns, chromatography, mass spectrometry systems, and data management software, it becomes possible to shorten analysis time in analytical labs, enhance data quality, reduce costs, and comply with requirements in an ever-changing regulatory environment. - Ingredient composition ratios and safety verification in lotions, emulsions, and foundations - Evaluation of functional ingredients that provide high moisture retention and whitening effects - Assessment of container packaging degradation and concerns regarding leachables If you are facing challenges with the analyses mentioned above, please contact us.

This technology brief introduces a direct analysis method for heterogeneous samples using an atmospheric pressure solid analysis probe (ASAP) in the sample inlet of mass spectrometry, eliminating the need for sample preparation. ASAP allows for the acquisition of mass spectra of mixtures within seconds without sample pretreatment, streamlining the workflow for monitoring target compounds in mixtures.

Achieving reliable trace quantification through matrix removal of various samples Sample pretreatment to enhance further cleanup effects With the advent of high-sensitivity analytical instruments, the importance of sample pretreatment, such as concentration and cleanup, is increasing. Matrix removal from various samples is essential for achieving more reliable trace quantification. In this live webinar, we will introduce the OASIS mixed-mode method development for enhancing cleanup effects. The Oasis 2×4 method is designed so that by selecting one of the four types of mixed-mode solid phases based on the chemical properties of the target component and implementing the recommended protocol for that solid phase, good results can be obtained. Program: - The necessity of sample pretreatment - Solid-phase extraction for matrix removal - Mixed-mode solid phase for further advanced cleanup - Oasis 2×4 method development

Photosensitive resins and materials that change with light have been developed to exhibit various functions suitable for applications such as coatings, biocompatible materials for medical use, electronic materials, and cosmetics. To achieve the desired physical properties, molecular-level interpretations are necessary, including molecular design of polymers and initiators, light absorption and activation, and control of reactivity. This seminar will introduce photosensitive materials, focusing on the changes in compounds before and after curing of light-curable resins using Tof MS, as well as the structural analysis applications of photogenerated acids and their impurities. Program: ■ Overview of photosensitive materials ■ Identification approaches for variable factor components using high-resolution mass spectrometry ■ Analysis of variations and structural estimation before and after curing of light-curable resins ■ Workflow for extraction and structural estimation of trace impurities ■ Structural analysis and impurity identification of photogenerated acids Target Audience: Individuals handling organic compounds for the development and quality control of materials and industrial products.

In recent years, with the advancement and enhancement of polymer materials, various additives for synthetic polymers with different functions have been used in optimized formulations. Among them, there are types of additives, such as hindered amine light stabilizers (HALS) and lubricants, that present challenges in solubility and detection methods, making analysis difficult. Additionally, when conducting structural analysis of multi-component polymers or terminal group analysis using pyrolysis gas chromatography-mass spectrometry (PyGC/MS), there are many pyrolysis products not registered in the EI method database, making analysis not straightforward. In this webinar, we will introduce two solutions to the challenges in the characterization of synthetic resins, along with practical examples. ■ Overview of additives for synthetic polymers ■ Actual quantitative analysis of HALS/lubricants ■ Examples of structural analysis of synthetic resins using PyGC/Q-Tof MS Target audience: Individuals handling organic compounds for the development and quality control of materials and industrial products.

Waters provides total solutions to support customers from sample preparation in food analysis and separation by high-performance liquid chromatography to mass spectrometry. In this webinar, we will introduce the basics of sample preparation methods, including examples of positive list simultaneous analysis, as well as analysis examples using LC/MS/MS. We will also showcase the latest Waters sample preparation equipment, such as the pressure-controlled manifold (Otto SPEcialist pressure manifold) and automatic liquid handling (Andrew Alliance). Program: ■ The necessity of sample preparation ■ Examples of food analysis applications using solid-phase extraction and QuEChERS methods ■ Introduction of the latest Waters sample preparation equipment - Otto SPEcialist pressure manifold - Waters amino acid analysis method and automatic liquid handling

Waters has developed the robust single quadrupole mass spectrometer RADIAN ASAP, equipped with the atmospheric pressure solid sample analysis probe (ASAP) ionization method, specifically designed for rapid, easy, and low-cost analysis of liquids and solids. It can directly ionize samples from liquids or solids, making it suitable for a wide range of applications and workflows. With excellent flexibility, operability, and speed, the RADIAN ASAP does not require complex sample pretreatment, separation, or analytical experience, helping you achieve more results. The multivariate analysis-capable LiveID software allows for real-time classification of samples analyzed with the RADIAN ASAP. Analytical results are immediately provided to the user, enabling instant decision-making based on the analytical information. In this webinar, we will first cover the basics of mass spectrometry, followed by an introduction to the principles, usage, features, and actual analysis cases of the RADIAN ASAP. Program: ■ Overview of mass spectrometry ■ Overview, usage, and features of RADIAN ASAP ■ Analysis cases in pharmaceuticals, chemistry, food, and forensics

Waters provides total solutions to support customers from sample preparation in food analysis to separation by high-performance liquid chromatography and mass spectrometry. In this context, we will introduce a simple and reliable high-speed amino acid analysis method (AccQ-Tag amino acid analysis method), which is important for food component analysis. We will also provide information on new products, such as the new mixed-mode column (Atlantis PREMIER BEH C18 AX Columns) that enables the high-speed analysis of 15 organic acids, as well as column selection for efficiently conducting various analyses, using examples like vitamins and sugars. Program: ■ About the amino acid analysis method (AccQ-Tag amino acid analysis method) ■ Column selection for food component analysis ■ Introduction of the latest columns

An explanation of the causes of tailing of ionic substances in the analysis of reverse phase systems and the selection of mobile phases for improvement.

This explains how to set separation conditions with a focus on the most commonly used reverse phase. It mainly describes the approach from the mobile phase side regarding how to effectively progress with condition setting.