Wide-pore HILIC column for glycoprotein analysis
Isolate glycoproteins based on the number and composition of sugar chains! Glycoprotein column
Glycosylation of proteins is a very important post-translational modification that regulates both the structure and function of proteins. Changes in glycan profiles can affect drug efficacy and immunogenicity, so glycosylated biopharmaceuticals require thorough characterization. In the characterization of glycoproteins, the wide-pore HILIC amide column (Glycoprotein BEH Amide, 300Å), which provides complementary information with reverse phase columns, allows for the separation of intact glycoproteins, glycoprotein subunits, or at the glycopeptide level based on the number and composition of glycans, enabling the acquisition of unprecedented glycoform information.
basic information
■Optimized wide-pore HILIC stationary phase for the separation of glycoforms from intact and digestible glycopeptides ■Generation of information on domain-specific glycosylation, regardless of MS detection ■Analysis of site-specific glycan occupancy ■High-resolution peptide mapping independent of peptide/glycan size ■Improved separation of large free N-linked glycans ■Conducting QC tests on filler gel batches using Glycoprotein Performance Test Standard
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Waters Corporation, headquartered in Milford, Massachusetts, USA, has played a pioneering role as a specialized manufacturer of liquid chromatography since its establishment in 1958. Actively engaged in the development of new products and technologies, it has grown into an international group company that supplies not only high-performance liquid chromatography but also mass spectrometers (MS) and thermal analysis instruments. Waters Japan started operations in 1973 (Showa 48) as the Japanese base of Waters Corporation. Inheriting the corporate ethos of the U.S. headquarters, we have made "Customer Success" our mission and continue to provide innovative technologies and lab solutions.