At the 47th Formulation and Creation Seminar held at Cross Wave Fuchu from September 8 to 9, we showcased the solid dosage manufacturing 3D printer 'M3DIMAKER' and a tablet press. We sincerely thank everyone who visited our booth during the event. For inquiries regarding the products you saw at the venue, please feel free to contact us at the information below. We will respond to inquiries received during the event in due course. For questions regarding the seminar or other products, we would appreciate it if you could contact our sales representative or reach out to us using the information below. We look forward to your continued support.

Thank you very much for visiting our booth at the "INTERPHEX Week Tokyo - 6th Bio Pharmaceutical EXPO" held recently. Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to the inquiries received during the event in due course. We appreciate your continued support of Higuchi Shokai. 【Exhibited Products】 - Sterile Capsule Filter Asepti Series (Advanced Microdevices) - Assembly Tubes and Bags (Advanced Microdevices, WHK BioSystems) - 3D Printer for Solid Dosage Manufacturing M3DIMAKER (FabRx) - Dissolution Testing Paddle Method/Basket Method 708-DS for Nanoparticle Formulations (Agilent Technologies)

We are pleased to announce that we will be exhibiting at the Secondary Battery Expo (Battery Japan). We will be demonstrating and showcasing products that are optimal for the transportation of battery materials. We understand that you may be busy during this period, but we sincerely look forward to welcoming many of you, along with your colleagues, to our booth.

We are pleased to announce that we will be exhibiting at the 6th Bio Pharmaceutical EXPO. At the venue, we will showcase a variety of unique products from both domestic and international sources, including new products. We understand that you may be busy during this period, but we sincerely look forward to welcoming many of you, along with your colleagues, to our exhibition.

We exhibited at the 27th International Food Ingredients/Additives Exhibition and Conference (ifia JAPAN 2022), held at Tokyo Big Sight for three days from May 18, 2022. Thank you very much for visiting our booth during the event. Thanks to your support, we were able to conclude the event successfully and with great acclaim. We believe this is entirely due to the warm support from all of you, and we would like to express our heartfelt gratitude on behalf of everyone involved. We also apologize for not being able to respond adequately due to the confusion on the day of the event. If you have any questions or requests for samples regarding the products we introduced at the venue, please feel free to contact us, and we will respond promptly. We look forward to your continued support.

From May 18th for three days, "ifia JAPAN 2022 / HFE JAPAN 2022" will be held. Our booth will mainly showcase food ingredients imported from Europe. We invite you to visit our booth during this opportunity. We look forward to your attendance.

Thank you very much for visiting our booth at the "HCJ 2022 50th International Hotel and Restaurant Show / 43rd Food and Catering Show / 22nd Kitchen Equipment Exhibition," held at Tokyo Big Sight for four days from February 15, 2022. Thanks to your support, we were able to conclude the event successfully and with great acclaim. We sincerely appreciate your warm support, and all of us involved would like to express our heartfelt gratitude. We also ask for your understanding regarding the confusion on the day of the event, which prevented us from providing adequate assistance. If you have any questions or requests for samples regarding the products we introduced at the venue, please feel free to contact us, and we will respond promptly. We look forward to your continued support. 【Exhibited Products】 - Seasoning for Thai cuisine (Green Curry Sauce) - Extra Virgin Olive Oil from Chile

Thank you very much to everyone who visited during the event. Thanks to you, the seminar was well-attended and concluded successfully. If you have any questions regarding the exhibits, catalogs, or materials related to the exhibitor seminars that you viewed at the venue, please feel free to contact us at the information below. We will also respond to inquiries received during the event in due course. For more details about the seminars and other products, please do not hesitate to reach out. We look forward to your continued support. ▼ Information on the held seminar "Handling Toxic Powders and Powders That Should Not Be Exposed to the Atmosphere" Tasks such as incorporating toxic powders into equipment or packaging them are very challenging due to the ease of exposure to the powders. How can we perform these tasks safely (protecting the workers and preventing dust explosions) and efficiently? We addressed this issue.

We will be exhibiting at the 34th Plant Show held at INCHEM TOKYO 2021. During the event, we will hold a seminar at the venue, so please be sure to stop by when you visit. We sincerely look forward to your attendance. ● Exhibition Information 【Booth Number】S2-E08 Entry is "completely pre-registration only." Please make sure to register as a visitor before attending (admission is free). (Link: https://www.jma-onlineservice.com/11all/jp_inchem/) ● Seminar Information 【Date and Time】November 17 (Wednesday) 12:50–13:20 【Venue】Exhibitor Seminar Room in Hall South 1 【Seminar Content】 "Handling Toxic Powders and Powders That Should Not Be Exposed to the Atmosphere" Tasks such as incorporating toxic powders into equipment or packaging them are very challenging as they can easily lead to exposure. How can we perform these tasks safely (protecting workers and preventing dust explosions) and efficiently? We will address this issue. 【Participation Fee and Method】 The participation fee is free, with a capacity of 70 people, and pre-registration is required via the website. (If there are available seats, attendance on the day is possible.)

We exhibited at the 10th CITE JAPAN / Cosmetics Development Exhibition held at Pacifico Yokohama for three days from May 19, 2021. Thank you very much for visiting our booth during the event. Thanks to your support, our exhibited product, JADE ALGA, was awarded 3rd place in the environmental category. We believe this achievement is entirely due to your warm support, and we would like to express our sincere gratitude on behalf of all involved. We also apologize for not being able to provide adequate assistance due to the confusion on the day of the event. If you have any questions or requests for samples regarding the products we introduced at the venue, please feel free to contact us, and we will respond promptly. We look forward to your continued support.

We exhibited at the 26th International Food Ingredients/Additives Exhibition and Conference (ifia JAPAN 2021), held at Pacifico Yokohama for three days from May 12, 2021. Thank you very much for visiting our booth during the event. Thanks to your support, we were able to conclude the event successfully and with great acclaim. We sincerely appreciate it on behalf of all involved. If you have any questions or requests for samples regarding the products we introduced at the venue, please do not hesitate to contact us. We look forward to your continued support. 【Products We Handle】 Ohly Co. / Yeast Extracts (for food, fermentation media, pet food) Vegenat Co. / Dried Vegetables (dried onion, puffed carrot, citrus fruits, parsley, spinach) Worlee Co. / Dried Mushrooms Dr. Suwelack Co. / Fermentation Seed Powder Felix Koch Offenbach Co. / Caramel Syrup Seagems Norway Co. / Seafood Powder Higuchi Shokai / Smoked Flavor Dried Yeast Powder "Grill Yeast"

We would like to introduce a live webinar hosted by Agilent Technologies. In December 2020, and in January and February 2021, a series of webinars focused on pharmaceutical analysis, ranging from small molecule drugs to biopharmaceuticals, will be held. In December, the theme will be "Small Molecule Drugs and Nucleic Acid Medicines (Active Ingredients - CMC - Quality Control)," and we will present on "Automation of Dissolution Testing and Regulatory Compliance Software." The seminar will introduce the automation of dissolution testers through auto-sampling, compliance with data integrity, and the nanoparticle dissolution testing system "Nano Dis."

From January 20 to 22, 2020, we exhibited at the 10th COSME Tech 2020, organized by Reed Exhibitions Japan Co., Ltd., held at Makuhari Messe. Thank you very much for visiting our booth during the event. Thanks to your support, we were able to conclude the event successfully. During the exhibition, in addition to bitop's Ectoin, we introduced products from Mirexus: ultra-high molecular weight 3D dendritic polymers, among others. If you have any questions regarding the exhibited items or the products listed in our catalogs, please feel free to reach out to us. We will respond to the inquiries received during the event in due course. We look forward to your continued support. <Product Introduced During the Event> bitop: Ectoin, Glycoin Mirexus: Ultra-high molecular weight 3D dendritic polymers Contipro: Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, New Hyaluronic Acid Derivatives Odycea: Plankton Glass Flower, Marine Bamboo, etc.

Higuchi Shokai Co., Ltd. has decided to cancel its participation in the 6th Interfex Week Osaka, which will be held at Intex Osaka from February 26 to 28 this year. This decision was made in light of the "Message to the Public Regarding Event Hosting" announced by the Ministry of Health, Labour and Welfare on February 20, prioritizing the safety of attendees and our employees. We sincerely apologize for any inconvenience this may cause to those who have already received information about our participation and ask for your understanding. The products we were planning to exhibit are listed on our company website. We would appreciate it if you could take a look.

We will be exhibiting at "Interfex Osaka" in February!! This time, we will have a booth showcasing many new release products. Additionally, we will be displaying related products regarding the management of testing and manufacturing data, which is a recent trend, so please stop by. <Highlights of New Release Products> ▶ Polarimeter compatible with JP, USP, and ChP ▶ Tablet testing machine compliant with Part 11 ▶ Benchtop granulation equipment ▶ Dynamic flowability testing device, etc. <Data Management Products> ▶ Dissolution testing management system ▶ Mechanical calibration system for dissolution testing apparatus ▶ Dissolution testing camera system ▶ Management system for tablet pressing mortars and pestles

We exhibited at the "1st Explosive and Disaster Risk Management Exhibition INCHEM TOKYO 2019." During the event, many people participated in both the seminars and the booth, and we were able to conclude it successfully. We sincerely thank everyone who visited us. If you have any questions regarding the seminars or other products, we would appreciate it if you could contact our sales representative or reach out to us using the information below. We look forward to your continued support. ▼ Information on the seminars held Safe Handling of Toxic Substances in Plants In chemical plants, it is necessary to handle various substances, each with different levels of toxicity and quantities. The seminar explained methods to mitigate exposure throughout a series of processes, from charging the reaction vessel to packaging the final product. Dust Explosion Countermeasures in Plants We provided explanations on explosion countermeasures in chemical plants, including the introduction of powders into reactors containing flammable gases and the handling of powders with dust explosion risks, based on reference flows. *For detailed information, please contact us.

On November 25, 2019, the 11th Powder Inhaler Research Symposium was held at the ANA Crowne Plaza Hotel Toyama in Toyama City, Toyama Prefecture. At the symposium, Mr. Chalermphon Wanawongthai from Meggle presented a lecture titled "Lactose in Dry Powder Inhaler - Formulation Strategies." Additionally, there was a panel exhibition showcasing various functional medical devices from the French company Nemera, as well as the German company Meggle's lactose hydrate for powder inhalers, InhaLacⓇ. We sincerely thank everyone who visited our booth during the event. We will respond to inquiries received during the event in due course. For inquiries regarding exhibited products or other products, please contact our sales representative or reach out using the information below. We appreciate your continued support.

We will be showcasing our products at the booths of various manufacturers. Please feel free to stop by when you visit the venue. We look forward to your visit. <Exhibitor: Evonik Japan Co., Ltd.> Exhibition: 21st Interphex Japan Booth Number: W20-29 [Main Products] Functional Polymer EUDRAGITⓇ Please consult us regarding formulation design, scale-up services, and oral DDS. <Exhibitor: Agilent Technologies, Inc.> Exhibition: 1st Pharma Lab EXPO Booth Number: A18-4 [Main Display Products] Dissolution Tester 708-DS (USP Apparatus 1/2/5/6) This device features excellent operability with automatic height adjustment and automatic tablet insertion, along with a robust design that excels in mechanical calibration compliance. Data Integrity Compliant Software This software is ideal for ensuring data integrity in dissolution testers, with features such as access management, data tampering prevention, and backup. [Information on Booth Presentations] During the event, we will hold a presentation at our booth on "Digitalization of Data Related to Dissolution Testing."

We will be holding a seminar focused on mechanical calibration and data integrity (DI) in relation to dissolution testing of formulations, which has recently garnered significant interest. Mechanical calibration, newly included in the reference information of the 17th revision of the Japanese Pharmacopoeia, has become well-known as a qualification evaluation method using a different approach and is being implemented by many companies. Additionally, there has been a longstanding requirement for the data generated from each process to be complete, and specific guidelines, including draft versions, have now been provided by various countries and organizations regarding DI. This seminar will include demonstrations and explanations related to mechanical calibration. We will also cover an overview of DI and its relationship with dissolution testing. We hope that by attending this seminar, participants will find it helpful in terms of future implementation, resolving issues, and deepening their knowledge. Seminar Content: - Qualification evaluation of dissolution testing equipment - Differences in mechanical calibration content between the Japanese Pharmacopoeia and various organizations - Practical training on mechanical calibration - Information on data integrity - Introduction to the equipment we handle

We held the "Dissolution Testing Technical Seminar 2018" at the Tokyo and Osaka venues. On the day of the event, Mr. Bryan Crist from Agilent Technologies in the United States gave a presentation on dissolution testing from the perspective of the latest guidelines. Additionally, Professor Yusuke Tanaka from Hiroshima International University spoke about "In vivo dissolution behavior of drugs in the gastrointestinal tract," and Mr. Satoru Arai from Toray Industries discussed "Key points for practical management in testing laboratories to accommodate the three poles." We sincerely thank everyone who attended despite their busy schedules.

We will be exhibiting the Dissolution Tester 708-DS at the Agilent Technologies booth during the "JASIS Analytical and Scientific Instruments Exhibition" held in September. We invite you to take this opportunity to visit us and see the product in person. We look forward to your attendance. <Pre-registration Information> As we anticipate congestion at the reception on the day of the event, we recommend pre-registering before your visit. Please complete your registration at the following URL: https://www.jasis.jp/regist/jp/pre_reg_landing.php

Thank you very much for visiting us during the event. Thanks to your support, we were able to conclude the event successfully. We sincerely appreciate it on behalf of all involved. We will respond to the inquiries received during the event in due course. Additionally, for inquiries regarding exhibited products or other products, we would be grateful if you could contact our sales representative or reach out via the "Contact Us" section at the top of our website. We look forward to your continued support. [Main Exhibits] Agilent Technologies 708-DS Dissolution Tester, BIO-DIS Dissolution Tester, 280-DS Mechanical Calibration System, Dissolution Testing Workstation Software (DWS), Inspector 500 Portable Raman Spectrophotometer, Work Assistance Robot (Reference Exhibit)

At the 43rd Annual Meeting of the Japanese Society of Cosmetic Science held on June 29 and 30, we conducted a panel exhibition at the venue. We introduced various products, including the ultra-high molecular 3D dendritic polymer PhytoSpherix from Canada's Mirexus and the micro-sponge technology from the U.S. company Health & Beauty Solutions, which garnered a lot of interest from attendees. We sincerely thank everyone who visited our booth during the event. PhytoSpherix is effective for moisturizing, film formation, and anti-aging, while the micro-sponge technology is ideal for stabilizing active ingredients, controlled release, and reducing irritation. If you are interested, please feel free to contact us.

Agilent Technologies, Inc. has published the "2017-2018 Edition Dissolution Testing Sourcebook (Digital Version - English)." The 2017-2018 edition includes details on various dissolution testing products, videos, application notes, and related links. It is also accessible on smartphones (data charges may apply for viewing the site).

We have started handling the high-performance material "Ultra High Molecular Weight 3D Dendritic Polymer PhytoSpherix," which can be used in lotions, emulsions, creams, gels, and more. This product, developed by the Canadian company Mirexus, is an ultra high molecular weight 3D dendritic α-glucan with a molecular size of approximately 70 nanometers, prepared from plants using a unique processing method. In vitro and in vivo tests have confirmed its high moisturizing and anti-aging effects. The formulation characteristics include being a nonionic polymer that does not affect emulsification systems. The aqueous solution is a colloidal solution that does not influence the rheology of the formulation. It has film-forming capabilities and can improve the texture after use. The dendritic chains can trap lipophilic substances, allowing for solubilization, stabilization, and enhanced permeability, while also serving as an effective ingredient and additive. ◆ For inquiries or consultations regarding the product, please contact us at TEL 03-5479-2820 (Business Development Department)

We exhibited at 【ifia JAPAN 2018 / HFE JAPAN 2018】 for three days starting from May 16! Thank you very much for visiting our booth during the event. Thanks to you, we were able to conclude the event successfully and with great enthusiasm. We believe this is all due to your warm support, and we would like to express our heartfelt gratitude on behalf of everyone involved. We also ask for your understanding regarding the confusion on the day, which prevented us from providing adequate assistance. If you have any inquiries regarding the products we introduced at the venue, we will respond promptly, so we appreciate your continued support.

The 33rd Annual Meeting of the Japanese Society of Pharmaceutical Sciences will be held, hosted by the Public Interest Incorporated Association, the Japanese Society of Pharmaceutical Sciences. This year, Okawara Manufacturing Co., Ltd. will present a poster, and our company will have a panel exhibition at the venue. We will introduce the "Dry Coating Device - Schunel Coater" at the venue. The Schunel Coater is a device that can apply polymer coatings to fine particles without using solvents, significantly reducing coating time compared to water-based coatings. Please feel free to stop by when you visit. *For more information about the Schunel Coater, click here: https://www.higuchi-inc.co.jp/assets/doc/pharmaceuticals/okawara_example/okawara_product_01.pdf

We will hold a seminar on the basics and applications of taste sensors in pharmaceutical evaluation. 【Morning Session】Basic Course 9:30~11:45 Beginner-friendly seminar 【Afternoon Session】Advanced Course 15:00~17:15 Seminar for those with measurement experience 【Organizers】 Organizer: Intelligent Sensor Technology Co., Ltd. Co-organizers: Higuchi Trading Co., Ltd., Medical Health Resource Development Institute 【How to Apply】 Please apply using the form at the bottom of the "Taste Seminar" page. http://mhrri.com/mikaku/ 【Program】 【Morning】 "Measurement Principles of Taste Sensors, Examples of Pharmaceutical Measurements, Precautions" Tomoko Kawakami, Intelligent Sensor Technology Co., Ltd. "Involvement in Compiling the Handbook for Assisting Medication in Infants and Children" Jun Kojima, Medical Health Resource Development Institute 【Afternoon】 "Operation of Taste Sensors, Evaluation Methods for Sensory Masking, Use of Relative Value Data, etc." Tomoko Kawakami, Intelligent Sensor Technology Co., Ltd. "Evaluation Methods for the Bitterness of Pharmaceuticals in Rats and Comparison with Taste Sensor Data" Jun Kojima, Medical Health Resource Development Institute

From February 20th, we jointly exhibited as Lampang Food Products at HCJ 2018 for four days! Thank you very much for visiting our booth during the event. Thanks to you, we were able to conclude the event successfully and with great enthusiasm. We believe this is all due to your warm support, and all of us involved would like to express our heartfelt gratitude. We also ask for your understanding regarding any confusion that may have occurred on the day, which prevented us from providing adequate assistance. If you have any inquiries regarding the products we introduced at the venue, we will respond promptly, so we kindly ask for your continued support.

In April 2017, we established a Quality Control Department directly under the president, and after a preparation period, it officially began operations in December. For the time being, we will conduct quality control operations related to the food ingredients and food additives that our company handles. We will promote a system that provides customers with peace of mind through the confirmation of the safety of the products handled by the Quality Control Department.