Sartorius Stedim Japan K.K. Official site

Process enhancement. Modify. Intensify. Amplify.

Biopharmaceutical manufacturers and CDMOs are facing the challenge of improving throughput and reducing costs to maintain competitiveness, making PI seem like a natural solution. However, the reality is that implementing the level changes that many expect is difficult. Sartorius Stedim will enhance key processes to help manufacturers align current demand with future developments, allowing them to experience the current benefits of PI while building for the future.

Industry-standard high-throughput bioreactor system optimized for process characteristic analysis.

<System Features> • An automated workstation with a built-in liquid handler capable of accommodating up to 24 single-use 250 mL culture vessels. • A continuous gas supply system that enhances process control by achieving greater similarity to larger-scale bioreactors. • Numerous analysis options, including BioPAT Viamass. • A user-friendly interface that supports strong data integrity. • An integrated camera that improves user interaction and system robustness.

A fully automated bioreactor system for the development of high-density cell culture processes!

【Other Features】 ■ Dramatically improves the productivity of lab work, allowing more time to be dedicated to perfusion culture research. ■ By utilizing the built-in DoE (Design of Experiments) functionality, it is possible to reach accurate results with fewer experiments, contributing to cost reduction compared to experiments conducted in a bench-top bioreactor. ■ In perfusion culture, a wide range of important parameters such as cell density, cross-flow rate, perfusion rate, bleed volume, bleed frequency, and type of hollow fiber can be optimized. ■ Demonstrates maximum strength in research aimed at perfusion culture using single-use bag culture systems and bioreactor STR. *For more details, please refer to the PDF document or feel free to contact us.

Bioreactor system for cell line development and process optimization.

■ The new features improve the performance of applications such as the following: - Clone selection - Optimization of culture media and feeds - High-density culture processes - Media exchange and passaging in cell therapy applications ■ The new variable deck reduces operator downtime and improves operator efficiency ■ The new Amber clone selection software makes the best clone decision process easier ■ The new Generation 2 liquid handler enables faster and more precise operations, capable of complex tasks such as liquid mixing and addition in multifactorial design of experiments (DoE) ■ Ambr15 is the industry-standard micro-bioreactor system used in research facilities worldwide ■ The addition of metabolite analysis equipment enables a development approach in accordance with Quality by Design (QbD) ■ Ambr15 significantly reduces the amount of culture media and consumables, thereby lowering the cost per experiment, in addition to saving on facility space, funding, and labor ■ Ambr15 contributes to better clone selection on-site, more media selection, and faster process optimization

A fully automated tool for acquiring and fully utilizing Raman spectroscopy data to build a robust cultivation process for the production of uniform and high-quality products.

- Fully automated bioreactor data acquisition system (including standardization and integration into SIMCA format using Raman spectroscopy) - Built-in Design of Experiments (DoE) software - Can be connected to the port of single-use culture bag Flexsafe STR

A single-use bioreactor system that dramatically enhances speed, quality, and productivity from process development to scale-up.

Large-scale single-use bioreactor system ■ Equipped with the analysis tool "BioPAT(R)" and the automation platform "BIOBRAIN" ■ Compatible with volumes from 12.5 L to 2000 L ■ Enhanced bioreactor operation

Seed culture for small-scale protein production.

<Process> – Production of proteins and cells for preclinical purposes – Seed culture for large bioreactors – GMP production <Cell> – Mammalian, insect, and plant cells – Suspended and adherent cells on microcarriers – Low to medium density microbial cultures – Shear-sensitive cells (stem cells or T cells) <Purpose> – Scale-up from shaker or T-flask – Rapid production of samples for preclinical trials – Proliferation and differentiation of stem cells – Production of recombinant proteins, mAbs, and vaccines – Continuous culture at a cell density of 1.5 × 10^8 cells/mL <Capacity> – Culture volumes from 100 mL to 100 L – Two body sizes: 20/50 and 200