Unchained Labs (アンチェインドラブズ） Official site

Accelerating formulation optimization for vaccine and pharmaceutical development.

Throughput: Up to 96 formulations within 6 hours Total flow range: 0.1 to 30 mL/min (depending on the tip) Flow ratio (water to organic): 1:1 to 5:1 Standard sample volume range (when FRR is 3:1): 400 µL to 2 mL Minimum input volume (including dead volume): 105 µL Continuous mode capacity range: NA Inline dilution: Yes Standard particle size range: 40 to 200 nm (depending on the formulation) PDI: Less than 0.2 (depending on the formulation) Encapsulation efficiency: Over 90% (depending on the formulation)

Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Throughput: 10 samples in 15 minutes Total flow rate range: 0.1 to 30 mL/min (depending on the chip) Flow ratio (water to organic) range: 1:1 to 10:1 Standard sample volume range (when FRR is 3:1): 1 to 6.5 mL Minimum input volume (including dead volume): 320 μL Continuous mode capacity range: 20 mL to infinity in continuous mode Inline dilution: Yes Standard particle size range: 40 to 200 nm* PDI: Less than 0.2* Encapsulation efficiency: Over 90%*

Accelerating formulation optimization for vaccine and pharmaceutical development.

Throughput: 10 mL/min per channel Total flow rate range: 0.1 to 30 mL/min (depending on configuration) Flow ratio (water to organic) range: 1:1 to 10:1 Standard sample volume range (when FRR is 3:1): 400 µL to 2 mL Inline dilution: Yes Standard particle size range: 40 to 200 nm (depending on formulation) PDI: Less than 0.2 (depending on formulation) Encapsulation efficiency: Over 90% (depending on formulation)

Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

【Specifications (Excerpt)】 ■Dimensions: Width 37 cm, Depth 54 cm, Height 33 cm, Weight 26 kg ■Electrical Characteristics: Universal input voltage 100–240 V AC, 50–60 Hz ■Computer: Separate computer with Windows 10 ■Connection: USB, TCP/IP (Service) ■Approvals: CE, FCC, CSA ■Regulatory Compliance: Optional 21 CFR Part 11 software package *For more details, please refer to the PDF document or feel free to contact us.

Up to 8 samples can be processed simultaneously! Automatic and hassle-free buffer exchange and concentration that used to be complicated!

【Specifications (Partial)】 <Applications> ■ Buffer exchange volume range: 0.5 to 8 mL ■ Number of formulations: Up to 8 formulations processed simultaneously ■ Sample types: Antibodies and other proteins, nucleic acids, AAV ■ Exchange time at full volume (96%, 10 mg/mL IgG used): 4.5 hours ■ Protein concentration (range): Up to 200 mg/mL ■ Target concentration accuracy: ±10% ■ Sample recovery rate: Over 96% *For more details, please refer to the PDF document or feel free to contact us.

[Video Available] Are you spending a lot of time and effort on buffer exchange and concentration work? You can streamline the sample preprocessing steps with this device.

For more details, please refer to the PDF document or feel free to contact us.

Introducing the details of the newly launched LNP production and screening device.

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