Participation in this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. The success or failure of the cultivation process significantly contributes to subsequent productivity, quality, and yield, even within the overall enhanced process. Therefore, the role of process development and optimization for cultivation is positioned as extremely important, and it is necessary to implement these approaches in conjunction with production bioreactors. As the number of considerations increases, there is a demand for cost and labor reduction, and our Amber System is the solution to achieve this. Since 2020, our model capable of perfusion cultivation has received positive feedback, and in the second installment, we will thoroughly convey this feature and its advantages. [Learnable Elements] - Evolved approaches to process development - Advantages of parallel implementation in multi-channel setups [Method of Hosting] Webinar recorded broadcast [Japanese, Free] *Special novelty items will be sent from our company to those who participated in all sessions from the first to the third on the same day.

Participation in this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. In recent years, the manufacturing processes of biopharmaceuticals have been shifting from large-scale equipment structures to enhancing individual processes to increase overall production volume. The core technology continues to heavily utilize single-use systems, and various approaches are available in both upstream and downstream processes to meet the goals of drug manufacturing. We will convey how to enhance your individual processes, including approaches, solutions, and ideal states, and will delve into specific topics in subsequent sessions. [Learnable Elements] - Approaches to process enhancement - Single-use bag bioreactors - Continuous chromatography technology [Method of Delivery] Recorded broadcast [in Japanese, free of charge] *Novelty items will be sent from our company to those who participated continuously from the first to the third session on the same day.

Participation in this webinar has ended. Those who wish to view it on demand can register for details and access it after registration. The mRNA vaccine plays a crucial role in combating SARS-CoV-2, and the necessity to produce mRNA has never been greater due to the ongoing development of treatments for various indications. In Part 2, the product manager and product specialist of the BioSMB system will explain how multi-column chromatography is superior to batch chromatography and how it can increase throughput by up to six times. They will also introduce traditional batch processes and demonstrate how BioSMB can be easily integrated into existing processes without compromising purification performance, throughput, or quality. [Topics] ▪ How batch chromatography limits throughput and increases resin costs ▪ How to improve throughput with less resin using BioSMB's multi-column cycling ▪ An analysis of how increased throughput reduces time to scale-up and the facility footprint.

Registration for this webinar has ended. Those who wish to view it on demand can register through the details and application section. In this webinar, we will explain the main features of the Amber system that correspond to various stages of clone selection under perfusion mimic conditions and complete perfusion conditions, as well as media and feed screening, and optimization of process parameters in small-scale bioreactors. [Topics] - Introduction of high-throughput capabilities for upstream intensification in various modes of Amber: perfusion mimic, ATF, TFF - Amber user case studies: showcasing performance in high-throughput enhanced process development - Discussion of a modular concept for enhanced seed trains utilizing perfusion and decision-making based on specific needs - Evaluation of time and cost advantages of modular seed trains based on predetermined process types Even if you cannot attend the live webinar, a link to the on-demand archive will be sent to those who registered.

Participation in this webinar has ended. Those who wish to view it on demand can register through the details and application section. mRNA vaccines play a crucial role in combating SARS-CoV-2, and the need to produce mRNA has never been greater due to the ongoing development of treatments for various indications. In this three-part webinar series, Sartorius experts will explain how improvements in processes, analytics, and tools are key to meeting demand. Part 1 will explore the processes, analytics, and tools needed to meet the high demand for mRNA, starting with the production of pDNA. We will introduce methods to achieve high yields of pDNA by ensuring the quality and purity of raw materials and optimizing the manufacturing process. [Topics] ▪ Examination of strategies to minimize contamination from product-derived impurities in IVT reactions ▪ Introduction of ready-to-use solutions for scalable pDNA chromatography purification ▪ Verification of the actual effectiveness of the HiP2 Plasmid Process Pack for purifying linearized pDNA

Participation in this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. In this webinar, we will introduce the overall picture of the solutions proposed by Sartorius, from process development to commercial manufacturing of AAV vector production. In the latter part, we will particularly focus on the purification aspect, which is considered a bottleneck in AAV vector manufacturing, and introduce chromatography products and their applications. 【Main Learning Content】 ▪Overview of AAV vector manufacturing ▪AAV vector manufacturing solutions proposed by Sartorius ▪Purification of AAV vectors using chromatography 【Recommended for】 ▪Those interested in gene and cell therapy technologies ▪Those involved in the research and development or manufacturing of gene therapies ▪Those struggling with the purification of AAV vectors 【Method of Delivery】 Webinar recorded broadcast 【In Japanese, Free】 *To participate in the webinar, you will need to install the Zoom app. Instructions for installation will be included in the confirmation email after registration.

Registration for this webinar has ended. If you would like to access the on-demand version, please register through the details and application link provided. In this webinar, you will learn about leveling up the process development of T cells. <Main Content> - Promotion of media screening and identification and optimization of CPP (Critical Process Parameters) - Profiling of CAR-T cells and clustering of donors - Reduction of development time and COGs *Even if you cannot attend the live broadcast, those who register will receive a link to the on-demand archive. Starts on July 30 (Friday) at 00:00 (International time: July 29 (Thursday) 11:00 AM EDT | 8:00 AM PDT | 5 PM CEST) Related website https://bit.ly/2V9rh9u

Participation in this webinar has ended. Those who wish to view it on demand can register through the details and application section. In this series, we will provide the best information to help with various best practices, important considerations, and process enhancement strategies for new and existing facilities. **Media Management to Promote Process Advancement** In this webinar, Stuart Tindal, PhD, Product Manager of Flexact Modular, and Myriam Lavie, Senior Product Manager of Fluid Management Technologies, will explain why media management is an important consideration for companies implementing process enhancements upstream. **Main Content** - Learn how to model and prepare various media configurations - Discuss scheduling and usage of media management equipment - Understand how to mitigate risks when facing quality issues or process failures **Related Website** https://bit.ly/3hOaIb1

Registration for this webinar has ended. Those who wish to view it on demand can register through the details and application link provided. In this series, we will deliver valuable information on various best practices, important considerations, and strategies for process enhancement in both new and existing facilities. **[PAT and Data Analysis]** In this webinar, technology consultant Henry Weichert and life sciences market manager Tiffany McLeod will introduce various PAT and data analysis methods that can be used alone or in combination for those aiming to enhance processes. **<Main Content>** - We will demonstrate how PAT and data analysis can address upstream process enhancements and downstream risks. - We will introduce Sartorius's PAT and data analysis tools throughout the product lifecycle. - You will learn what actions can be taken to successfully enhance processes. **[Related Website]** https://bit.ly/3hOaIb1

Registration for this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. Announcement of a two-part webinar by two specialists: 1: New product kSep50: A single-use centrifugation system that can scale for concentration, cleaning, and recovery. By processing high-density cells in the fields of harvest, clarification, cell therapy, vaccine manufacturing, and blood processing, it addresses the challenges of traditional centrifugation and filtration-based technologies. 2: Advanced medical and cell therapy research and development, process development, and manufacturing solutions provided by Sartorius. In this webinar, we will also introduce a lineup of products and solutions that support research and development, process development, and manufacturing of cell-based therapies, primarily CAR-T, MSC, and iPS cells, more quickly and efficiently. - Introduction of products effective for accelerating process development and scale-up. - Introduction of consistent and cost-effective commercial-scale bioprocess products. Speaker: Ryosuke Fujimori (Technical Sales Specialist)

Participation in this webinar has ended. Those who wish to access the on-demand version can register for details and viewing. Contaminated regenerative medicine products and gene therapy products (Advanced Therapy Medicinal Products: ATMP) pose a risk to the lives of patients receiving treatment. The current international pharmacopoeia requires 14 days for sterility testing, but the typical shelf life of an ATMP is 48 hours. We have developed a qPCR testing method that can detect bacterial and fungal contamination in just under 3 hours before treatment begins. In this webinar, we will present a validation study designed to evaluate the detection capabilities of bacteria and fungi in accordance with EP 5.1.6, USP <1223>, and <1071>. [Related Homepage] https://www.sartorius.com/en/applications-jp/quality-control-testing-jp/microbiological-quality-control-jp/rapid-testing-jp/bacterial-detection-jp

Announcement of Webinar Hosting. If you cannot participate in the live webinar, please register first. Those who register will receive a link to the on-demand archive. Date: June 14, 2021 Time: 15:00 The main purpose of cryopreservation is to preserve biological specimens. This technique is very important for biotechnology. However, the freezing-thawing process puts stress on all cells and tissues. In this webinar, we will explain how to overcome these challenges and provide suggestions regarding the survival rate issues after cryopreservation, as well as safe and efficient methods for cell cryopreservation. Topics: • Basics and limitations of cryopreservation • Selection of cryopreservation media • Troubleshooting • Safety tips and considerations <Instructor Introduction> Oren Ben-Yosef, PhD Sartorius, Advanced Therapies, Product Manager Bachelor of Science in Biotechnology Engineering from Technion - Israel Institute of Technology, and PhD in Medicine. Focused on research related to the culture and differentiation of embryonic stem cells and induced pluripotent stem cells. Please register from the related link below.

Participation in this webinar has ended. Those who wish to view it on demand can register for details and access after registration. The COVID-19 vaccine demonstrates the potential of the mRNA-based platform; however, so far, manufacturers have primarily focused on the safety and efficacy of mRNA vaccines and have not placed much emphasis on optimizing future production and purification processes. In this webinar, experts will discuss the current approaches and bottlenecks in mRNA production and will hold a panel discussion on the vision for optimized next-generation processes. Key learning objectives: • The real challenges in mRNA manufacturing and Sartorius's efforts to develop innovative solutions in collaboration with customers • The importance of flexibility in mRNA purification • Introduction to rapid analytical monitoring methods for IVT reactions using CIMac PrimaS Thursday, May 27 Session 1: 16:00 - 17:00 Session 2: 23:30 - 24:30 (ends at 0:30 on May 28)

The main purpose of cryopreservation is to preserve biological specimens. This technique is very important for biotechnology. However, the freezing-thawing process puts stress on all cells and tissues. In this webinar, we will explain how to overcome these challenges, address issues related to survival rates after cryopreservation, and provide safe and efficient methods for cell cryopreservation. Topics: • Basics and limitations of cryopreservation • Selection of cryopreservation media • Troubleshooting • Safety tips and considerations Even if you cannot attend the live broadcast, please register first. Those who register will receive a link to the on-demand archive. Instructor Introduction Oren Ben-Yosef, PhD Bachelor of Science in Biotechnology Engineering from the Technion - Israel Institute of Technology, and a Doctor of Medicine. Focused on the culture methods and differentiation of embryonic stem cells and induced pluripotent stem cells. Biological Industries and Sartorius will continue to develop a strategic partnership in chemical technology for cell therapy and regenerative medicine. We will continue to provide high-performance stem cell-related products to sustain the benefits gained over the coming years.

Registration for this webinar has ended. Those who wish to access the on-demand version can register for details and viewing. How scalable and intensified is your CAR-T process In this webinar, Dr. Qasim Rafiq, Associate Professor of Cell and Gene Therapy Bioprocess Engineering at University College London, will introduce the process control strategies developed to improve CAR-T yield. Webinar Overview: - Consistent scalable expansion of CAR-T cells in stirred-tank bioreactors - Reduction of variability - Establishment of management strategies for enhancing the CAR-T process

Participation in this webinar has ended. Those who wish to view it on demand can register for details and access it after registration. James Edwards, a product development scientist specializing in automated cell culture technology, and Donald Traul, a senior field application specialist, will give a presentation based on the following propositions using actual examples of Ambr 15 and Ambr 250: - Efficient clone selection - Screening of optimal media and feed media - Optimization of process parameters in simulated perfusion or perfusion - The fastest route to high-density cell culture processes

Participation in this webinar has ended. Those who wish to view it on demand can register through the details and application section. Priyanka Gupta, Head of Market Entry Strategy in the protein-based therapy field, will review the industry's needs for process enhancement and consider steps to determine optimal enhancement strategies. Key Learning Objectives: - Identify modular and scalable solutions that can increase productivity by up to four times in both upstream and downstream processes. - Learn how to reduce upfront investment costs by 50% and increase annual product revenue by nearly 50%. - Discover data analytics and automation tools that provide robust process control and significantly impact product cost and quality. Cost-conscious biopharmaceutical manufacturers and CDMOs are facing increasing pressure to accommodate various modalities and batch sizes. Process enhancement is a logical solution. We will help you determine where and how to enhance your processes in the following ways: - Improving productivity - Reducing cost of goods sold (COGS) - Increasing flexibility - Reducing footprint - Shortening timelines

Participation in this webinar has ended. Those who wish to view it on demand can register through the details and application section. In this webinar, the head of protein-based therapeutics will identify the industry's enhanced processing needs, explore solutions using a decision criteria matrix, and determine the optimal enhancement strategy. Discover modular and scalable upstream and downstream solutions that can lead to up to a 4-fold increase in productivity. We will guide you to modular and scalable solutions that can reduce capital investment costs by 50% and increase productivity by four times. You can find data analytics and automation tools that provide robust process control, significantly impacting product and quality costs.

We will hold three webinars in March. - March 11 at 12:00 AM | Integrated mRNA production process from E. coli to highly purified mRNA - March 24 at 12:00 AM | Virtual demo and overview of the BioSMB multi-column chromatography platform - March 30 at 5:00 PM & March 31 at 12:00 AM | Extractables Assessments (with ExSim) - sessions will be split into two parts For customers who cannot attend the webinars, an on-demand version will also be available. Please check the attached file or the displayed URL for more details.

Participation in this webinar has ended. Those who wish to view it on demand can register through the details and application section.