We are pleased to announce that Sartorius Japan has launched the new product, the Octet R8e BLI Biomolecular Interaction Analysis System. The Octet R8e offers higher sensitivity, longer automatic measurement times, and flexible throughput compared to previous models, providing excellent performance and reliability. We will be holding a product launch event on Tuesday, July 15, so please join us. In addition to presentations by Mr. Shigemune Kumaji from Epsilon Molecular Engineering, an Octet user, and Mr. Ryo Matsunaga from the University of Tokyo, we also have a workshop on intermolecular interaction measurements planned. We look forward to your participation! Event Overview: Date and Time: Tuesday, July 15, 2025, starting at 13:30 Venue: Hibiya Mitsui Conference (Room 1, 8th Floor, Tokyo Midtown Hibiya) Participation Fee: Free Capacity: 40 people (Registration will close once capacity is reached) If you wish to participate, you can apply using the form at the bottom of the details and application page.

At the Dialogue 20th Anniversary "PHARMA & BIOTECH 2025," we will be sponsoring with an exhibition and seminar featuring Sartorius products! This seminar is organized by Dialogue and will feature presentations and poster sessions over two days, focusing on various modalities in drug discovery, primarily for pharmaceutical companies. Sartorius will have an exhibition booth for two days, showcasing the Octet biomolecular interaction analysis system, Incucyte live cell analysis system, and iQue HTS cytometer. Additionally, on Tuesday, August 5, we will present "Cross-platform analysis of binding and function of anti-HER2 antibody-drug conjugates (ADCs)." We hope to see you there! *Please select "Sartorius Japan" as the source of your knowledge about the site.

On July 5, 2024, we will provide on-demand streaming of the recorded seminar given by Professor Kazutaka Tsujikawa from Osaka University at our luncheon seminar during the 51st Annual Meeting of the Japanese Society of Toxicology, available for a limited time. We encourage you to register and watch. Title: Support for Life Sciences and Drug Discovery Research by AMED BINDS at the Drug Discovery Science Research Support Center, Osaka University, and the Utilization of Incucyte Abstract: The AMED Life Sciences and Drug Discovery Research Support Infrastructure Project (BINDS) is a research support initiative aimed at connecting the results of Japan's outstanding life sciences research to drug discovery and development. At the Drug Discovery Science Research Support Center of Osaka University, we have established a system to seamlessly support advanced equipment setup and utilization, exploration of drug discovery target molecules, provision of compound libraries, implementation of high-throughput screening, and structural development of compounds as well as in vivo pharmacokinetics and safety testing, following the acceptance of BINDS. This seminar will introduce examples of the use of Incucyte in toxicity evaluations utilizing spheroids and organoids, along with these distinctive support features. Viewing Period: December 17, 2024 – January 17, 2025

The Sartorius Life Science Academy 2024, which was scheduled to be held in August, has now been changed to an online format. In this session, Mr. Shunsuke Kitajima from the Cancer Research Institute of the Public Interest Incorporated Foundation and Mr. Hideya Sakaguchi from the RIKEN Center for Biosystems Dynamics Research will discuss application examples of our Incucyte live cell analysis system in their respective research. Please see below for the abstracts and program. Additionally, our application scientists will also introduce new applications of Incucyte. We hope you will join us.

We will be exhibiting at the "76th Annual Meeting of the Japanese Society for Biotechnology" held at the Tokyo Institute of Technology, Ookayama Campus from September 8 to 10. At our booth, we will showcase the Octet biomolecular interaction analysis system. On the second day of the conference, we will host a luncheon seminar featuring Dr. Akiyo Kato from Nagoya University. We hope you will stop by! **Booth** Booth Number: West Building 9, 1F - 14 **Luncheon Seminar** September 9 (Monday) 11:30 AM - 12:30 PM 2L-B (Venue B, West Building 9, W9-324) Speaker: Dr. Akiyo Kato Graduate School of Bioagricultural Sciences, Nagoya University Title: Production of Fab Antibodies by Microorganisms and Case Studies of Affinity Measurement Using Trace Samples Abstract: In our laboratory, we are developing techniques for the production and evaluation of single B cell-derived monoclonal antibodies using an E. coli cell-free protein synthesis system, as well as methods for large-scale production of Fab antibodies utilizing recombinant production systems by microorganisms. In this presentation, I would like to mainly introduce case studies of BLI method analysis using trace samples, including affinity analysis of Fab antibodies produced in microbial systems, analysis using solutions of difficult-to-purify or unidentified antigens, and affinity analysis between proteins and DNA.

We are pleased to announce that Sartorius Japan Co., Ltd. will be exhibiting at JASIS 2024, which will be held from September 4 (Wednesday) to September 6 (Friday) for three days. We plan to showcase a variety of products including pipettes, electronic balances, ultrapure water production systems, and filters. We will also participate in a new technology presentation, so please stop by. Venue: Makuhari Messe International Exhibition Hall Booth Number: 8B-405 Participation Fee: Free 【Highlights of the Exhibition】 - Laboratory Balance Quintix Pro - Electronic Pipette Picus 2 - Alium Mini Compact Ultrapure Water Production System - Universal Pump Sterisart for Clean Environments 【New Technology Presentations】 - September 5 (Thursday) 10:30-11:00 (Makuhari Messe Conference Room 104) Introduction of the next-generation electronic pipette that provides comfortable pipetting (OPEN API compatible) - September 6 (Friday) 15:00-15:30 (TKP (formerly APA) Venue No. 9) Introduction of the new Sartorius Semi-Micro Balance (Innovation in work efficiency due to a significant leap in measurement time)

We will participate in the online seminar "Cell Culture Technology 2024" hosted by DialoG Co., Ltd. We will provide various information on the latest trends in cell culture technology. Our company will present on the topic "The Importance of Continuous Image Evaluation from Screening to QC." Please be sure to register! *When registering, please select "Sartorius Japan" as the source of how you learned about the site. Date and Time: April 25, 2024 (Thursday) From 13:00 (scheduled) Format: Online Participation Fee: Free (up to 200 participants) Capacity: 250 participants Deadline: Until 17:00 on April 18, 2024 (Thursday) *Registration will close as soon as the capacity is reached. [Our Seminar] Title: The Importance of Continuous Image Evaluation from Screening to QC Speaker: Shohei Shimonishi (Field Application Scientist, Sartorius Japan Co., Ltd.)

The Octet system has a proven track record not only in kinetics analysis but also in the specific quantitative measurement of biomolecules based on Binding Rate. Compared to ELISA and HPLC, it allows for simple, quick, and highly accurate quantitative measurements. Octet quantitative analysis for screening expression libraries, optimizing culture conditions, and checking purifications contributes to the simplification of processes in biopharmaceutical development, enabling the acceleration of the entire development flow. If you wish to view the On-Demand Webinar, please fill in your customer information from the "Details & Application" link below. After completing your application, the On-Demand viewing link will be displayed on the screen. The webinar presentation slides can be downloaded from the related catalog below.

The World Health Organization (WHO) recognized on March 11, 2020, that the novel coronavirus (COVID-19) infection had reached a pandemic level. Currently, there is a demand for the acceleration of research on treatments and vaccine development for this infection. To expedite the development of therapeutics and vaccines, advanced analytical techniques are crucial for rapid screening of many candidates and for determining the most promising candidates. The Octet system enables real-time assays of biomolecular interactions using BLI technology and allows for high-throughput screening and evaluation of candidates through simultaneous measurement of multiple samples. As a result, data from the Octet system has been featured in many papers that bring breakthroughs related to the biological research of COVID-19 and vaccine and therapeutic development. ■ Ended (2020/10/20) 【Update Information】 If you wish to view the webinar, please fill in your customer information from the "Details & Application" link below. After completing your application, an On-Demand viewing link will be displayed on the screen. The webinar presentation slides can be downloaded from the related catalog below.

One of the most important steps in the antibody development workflow is how to efficiently screen excellent antibodies from a large number of antibodies produced using immunological methods and phage display methods. The conventional ELISA method, which analyzes based on affinity, cannot distinguish between clones that express low-affinity antibodies at high levels and clones that express high-affinity antibodies at low levels; therefore, methods that analyze based on kinetic information become effective. The Octet system enables the identification of clones that produce high-affinity antibodies, which is considered difficult with the ELISA method. Obtaining kinetic information at an earlier stage in the development of antibody drugs and diagnostic agents can lead to the simplification of subsequent processes and accelerate the entire development flow. ■ Completed (2020/11/17) 【Update Information】 If you wish to view the webinar, please fill out your customer information from the "Details & Application" link below. After completing your application, an On-Demand viewing link will be displayed on the screen. The webinar presentation slides can be downloaded from the related catalog below.

The characterization analysis of the epitope regions of target proteins can determine whether multiple clones share the same epitope or recognize different regions of the target protein, providing detailed information for antibody development. Epitope binning, which classifies antibodies based on the antigen regions or epitopes they bind to, is an effective assay for the development of antibody drugs and diagnostic agents. The Octet system enables high-throughput epitope binning assays through real-time assays of biomolecular interactions and simultaneous measurements across multiple channels, accelerating antibody development. In this seminar, we will provide an overview and explanation of the usefulness of epitope binning assays, as well as examples of applications using the Octet system. ■ This has concluded (2020/9/29) 【Update Information】 If you wish to view the webinar, please fill in your customer information from the "Details & Registration" link below. After completing your registration, an On-Demand viewing link will be displayed on the screen. The webinar presentation slides can be downloaded from the related catalog below.

Sartorius Stedim Japan Co., Ltd. has decided to actively withdraw from participation in the "Regenerative Medicine EXPO Osaka" (Intex Osaka) scheduled to be held from February 26, considering the health and safety of participants and stakeholders in light of the ongoing spread of the novel coronavirus infection. Although we will have a booth prepared, we will not be displaying products and will provide unmanned support. As a result, all seminars related to the following products and technologies, which would gather a large number of participants, will be canceled. We sincerely apologize to those who were hoping to attend and ask for your understanding in this matter. Additionally, information and catalogs regarding the seminar-related products and services can be viewed below. If you are interested, please feel free to contact us. ▼ Canceled Seminars February 26 (Wed) 11:00–11:30 Manufacturing and Process Development of Viral Vectors February 28 (Fri) 11:00–11:30 Testing Packages for Cell Therapy and Gene Therapy ■ Contact Information Representative: 03-6478-5201 hp.info@SARTORIUS.com