ティー・エイ・インスツルメント・ジャパン （TAInstruments） Official site

How about one for the lab? Introducing the Discovery DSC series, the world's most outstanding and highly versatile differential scanning calorimeter.

Features and Benefits - Patented new Fusion CellTM technology Unmatched performance in baseline flatness, sensitivity, resolution, reproducibility, and reliability - Innovative "app format" touchscreen Enhanced operability with easy One-Touch-AwayTM functionality, making data acquisition easier than ever - Reliable linear autosampler with 54 programmable tray positions 24-hour operation, flexible measurement programming, and automatic calibration routines available - Modulated DSC (MDSC) Most efficiently separates complex thermal events, improving data interpretation reliability - Wide temperature range with electric cooling options Eliminates the running costs of liquid nitrogen and enables long-term continuous operation using an autosampler - Tzero press and pan Allows for quick, simple, and highly reproducible sample preparation

This is an introduction to protein analysis cases and related equipment by analysis specialists. This time, we will cover three devices: ITC, TAM, and NanoDSC!

At TA Instruments, we handle a wide range of equipment including "thermal analysis instruments," "viscoelastic measurement devices and rheometers," "microcalorimeters (for biological and medical fields)," and "fatigue testing machines." This time, we will introduce three types of devices that are particularly suitable for evaluation in the fields of biology, bio, and pharmaceuticals, known as "microcalorimeters." 【Agenda】 P3~ Introduction to ITC (Isothermal Titration Calorimeter) Evaluation of binding constants of enzymes and inhibitors Kinetic evaluation of enzyme reactions and the effects of inhibitors P6~ Introduction to NanoDSC (Differential Scanning Calorimeter) Case studies on the stability and denaturation behavior of proteins Evaluation of the dependence of protein denaturation temperature on Zn2+ ion concentration P9~ Introduction to TAM (Isothermal Calorimeter) Evaluation of the efficacy of anticancer drugs through metabolic measurements of tumor cells

Device accessories

Features and Benefits - Compatible with cooling accessories, supporting a wide operating temperature range of -180 to 725 ℃ - Accessories can be installed by the user, allowing for immediate installation when needed for material research - Three method segments (image capture, video, dynamic video) make simultaneous capture of images and videos during experiments easier than ever. Dynamic video uses a unique command that captures video clips only when thermal events are detected in the heat flow of the test sample, reducing the size of video footage by not capturing video while the heat flow is inactive.

This is an introduction to a protein analysis case study by a specialist in analysis. This time, we evaluated the substrate degradation rate and the effects of inhibitors using ITC.

At TA Instruments, we handle a wide range of equipment, including "thermal analysis instruments," "viscoelastic measurement devices and rheometers," "microcalorimeters (for the life sciences and medical fields)," and "fatigue testing machines." This time, we will introduce three types of equipment known as "microcalorimeters," which are highly suitable for evaluation in the life sciences, biotechnology, and pharmaceutical fields. ◆ Isothermal Titration Calorimeter (ITC) The isothermal titration calorimeter (ITC) is a device that detects the heat changes associated with titration at a constant temperature, primarily used for analyzing molecular interactions. It measures the minute heat changes that occur when molecules bind to each other, allowing for the determination of binding ratios (n), binding constants (Ka), and changes in enthalpy of binding (ΔH) from the resulting titration curves.

This is an introduction to a protein analysis case study by a specialist in analysis. This time, we evaluated the changes in denaturation temperature behavior with the addition of Zn2+ using NanoDSC.

At TA Instruments, we handle a wide range of equipment including "thermal analysis instruments," "viscoelastic measurement devices and rheometers," "microcalorimeters (for biological and medical fields)," and "fatigue testing machines." This time, we will introduce three types of microcalorimeters, which are very suitable for evaluation in the fields of biology, bio, and pharmaceuticals. ◆Microcalorimeter for Biological Use (NanoDSC) The microcalorimeter for biological use (nano DSC) is the most widely used thermal analysis instrument for the physical property evaluation of a broad range of materials including polymers, pharmaceuticals, food, biological substances, organic compounds, inorganic compounds, and composite materials.

Provides high reliability! An excellent tool for measuring a wide range of molecular interactions.

■Measurement range: -10°C to 130°C ■Cell capacity: Standard capacity (1.0 mL), low capacity (190 µL) ■Stirring speed: 10 to 1000 rpm ■Temperature control: Solid-state active heating and cooling ■Auto-sampler: 96-well, temperature controlled ■Software: ITCRun, NanoAnalyze ■Cleaning function: Automatic cleaning, user-selectable system cleaning routine

This is the lecture material posted on YouTube ~DSC Basic Edition 1~. It is available for free download, so please feel free to make use of it.

We would like to introduce a YouTube course on DSC from TA Instruments, the world leader in thermal analysis. What can you learn from DSC? How should you analyze the graphs? The graphs are different between the first and second measurements... why is that? We are offering a groundbreaking tool to solve these questions for free. Lecture materials are also available for free on the Ipros site, so please make use of them.