Unchained Labs (アンチェインドラブズ） Official site

Seamlessly transition from formulation condition screening to scale-up and GMP manufacturing. Accelerate LNP product development.

*Please check the respective product pages or catalog for detailed specifications.

Accelerating formulation optimization for vaccine and pharmaceutical development.

Throughput: Up to 96 formulations within 6 hours Total flow range: 0.1 to 30 mL/min (depending on the tip) Flow ratio (water to organic): 1:1 to 5:1 Standard sample volume range (when FRR is 3:1): 400 µL to 2 mL Minimum input volume (including dead volume): 105 µL Continuous mode capacity range: NA Inline dilution: Yes Standard particle size range: 40 to 200 nm (depending on the formulation) PDI: Less than 0.2 (depending on the formulation) Encapsulation efficiency: Over 90% (depending on the formulation)

Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Throughput: 10 samples in 15 minutes Total flow rate range: 0.1 to 30 mL/min (depending on the chip) Flow ratio (water to organic) range: 1:1 to 10:1 Standard sample volume range (when FRR is 3:1): 1 to 6.5 mL Minimum input volume (including dead volume): 320 μL Continuous mode capacity range: 20 mL to infinity in continuous mode Inline dilution: Yes Standard particle size range: 40 to 200 nm* PDI: Less than 0.2* Encapsulation efficiency: Over 90%*

Accelerating formulation optimization for vaccine and pharmaceutical development.

Throughput: 10 mL/min per channel Total flow rate range: 0.1 to 30 mL/min (depending on configuration) Flow ratio (water to organic) range: 1:1 to 10:1 Standard sample volume range (when FRR is 3:1): 400 µL to 2 mL Inline dilution: Yes Standard particle size range: 40 to 200 nm (depending on formulation) PDI: Less than 0.2 (depending on formulation) Encapsulation efficiency: Over 90% (depending on formulation)

Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

【Specifications (Excerpt)】 ■Dimensions: Width 37 cm, Depth 54 cm, Height 33 cm, Weight 26 kg ■Electrical Characteristics: Universal input voltage 100–240 V AC, 50–60 Hz ■Computer: Separate computer with Windows 10 ■Connection: USB, TCP/IP (Service) ■Approvals: CE, FCC, CSA ■Regulatory Compliance: Optional 21 CFR Part 11 software package *For more details, please refer to the PDF document or feel free to contact us.

Simultaneous measurement of 12 applications such as thermal stability, sizing, and viscosity from trace samples.

【Specifications (Excerpt)】 ■ Minimum sample volume: 9 μL, sealed capillary ■ Number of simultaneous measurements per experiment: 48 ■ Sample temperature range: 15-95℃ ■ Sample concentration range: 0.05 to 300 mg/mL IgG (depending on the protein) ■ Heating rate: 0.1 to 10℃/min ■ Temperature control accuracy: ±1℃ (<70℃), ±1.5℃ (>70℃) ■ Physical dimensions: Width 54 cm, Depth 50 cm, Height 58 cm, Weight 50 kg *For more details, please refer to the PDF document or feel free to contact us.

[Video Available] Are you spending a lot of time and effort on buffer exchange and concentration work? You can streamline the sample preprocessing steps with this device.

For more details, please refer to the PDF document or feel free to contact us.

No complicated workflows needed! Only 2μL of sample volume required. Measure up to 96 samples in just 5 minutes.

【Specifications (Excerpt)】 ■Dimensions: Width 37 cm, Depth 46 cm, Height 33 cm, Weight 21 kg ■Operating Voltage: 24 VDC, 30 W (maximum) ■Connections: USB, TCP/IP (Service, SiLA) ■Light Source: Xenon Flash Lamp ■Detector: UV/Vis Multispectral Photometer ■Certifications: CE, FCC, CSA ■Wavelength Range: 230-750 nm ■Wavelength Accuracy ・Below 400 nm: ±1 nm ・Above 400 nm: ±2 nm *For more details, please refer to the PDF document or feel free to contact us.

Up to 8 samples can be processed simultaneously! Automatic and hassle-free buffer exchange and concentration that used to be complicated!

【Specifications (Partial)】 <Applications> ■ Buffer exchange volume range: 0.5 to 8 mL ■ Number of formulations: Up to 8 formulations processed simultaneously ■ Sample types: Antibodies and other proteins, nucleic acids, AAV ■ Exchange time at full volume (96%, 10 mg/mL IgG used): 4.5 hours ■ Protein concentration (range): Up to 200 mg/mL ■ Target concentration accuracy: ±10% ■ Sample recovery rate: Over 96% *For more details, please refer to the PDF document or feel free to contact us.

It enables the monitoring of potency and purity throughout the entire workflow of lentivirus research and development, accelerating gene therapy development.

For more details, please refer to the PDF document or feel free to contact us.

Automating powder weighing with high precision. The number of samples that were difficult to handle manually can now be processed in a single day.

【Example of Configuration】 ■ Rack for Powder Storage & Dedicated PDT Head ■ Arm for Powder and Liquid Dispensing ■ Arm for Vial and Plate Transport ■ Vial Rack Storage ■ Electronic Balance with Camera ■ LEA (Automatic Integration of Analytical Data) *For more details, please refer to the PDF document or feel free to contact us.

High-throughput screening for new material development. The number of samples that were difficult to handle manually can now be conducted in one day.

【Example of Composition】 ■ Plate / Vial Gripper ■ Waste Box ■ Electronic Balance with Camera ■ PTD Rack ■ Stirring Station ■ Powder Station ■ Temperature Control ■ Cap Opening and Closing ■ Liquid Dropping Arm *For more details, please refer to the PDF document or feel free to contact us.