Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. Under GMP manufacturing management, regulations require the implementation of integrity testing after product filtration, but in recent years, there has been an increasing demand for a high level of Quality Risk Management (QRM). Sartorius offers the Sartocheck 5|5 plus, a filter integrity testing device equipped with QRM capabilities that exceed those requirements, as well as the highest level of data integrity. In this webinar, we will introduce the features of Sartorius' filter integrity testing devices and the actual testing methods. 【Seminar Overview】 March 2, 2023 (Thursday) from 15:00 (approximately 35 minutes) Webinar recorded broadcast [Japanese, Free] *We sincerely apologize, but participation from companies in the same industry and email addresses other than those of your organization is not permitted. Thank you for your understanding.

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. Buffer exchange and concentration are critical processes in downstream processing. The introduction of single-use TFF (SUTFF), which can prevent cross-contamination and does not require cleaning validation, is progressing. In this webinar, we will introduce SUTFF devices for ADCs that were just launched last year, as well as SUTFF devices and TFF filters from pilot scale to production scale. 【Seminar Overview】 ▪ Date: February 16, 2023 (Thursday) from 3:00 PM (approximately 40 minutes) ▪ Format: Webinar recorded broadcast [Japanese, Free] *We sincerely apologize, but participation from companies in the same industry and email addresses other than those of your organization is not permitted. Thank you for your understanding.

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. Leaks are cited as one of the top three concerns regarding the use of single-use products. The rising cost of active pharmaceutical ingredients and the aspect of operational safety have also drawn attention to non-destructive testing before use. In this webinar, we will delve into Sartorius's concept of the integrity of single-use bags, focusing on pinhole size, water pressure, and intended use. 【Seminar Overview】 ▪ Date: February 2, 2023 (Thursday) from 3:00 PM (approximately 40 minutes) ▪ Method: Webinar recorded broadcast [Japanese, Free] If you are unable to participate on the day, please register first. We will send you the recorded video and a download URL for related product materials at a later date. *We apologize, but participation from other companies in the same industry and email addresses not associated with your organization is not permitted. Thank you for your understanding.

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. In the biotechnology industry, monoclonal antibodies (mAb) are mainstream, but there are challenges that need to be addressed to manufacture pharmaceuticals without compromise, such as ease of use, scalability, speed, footprint, and cost. This webinar will explain how Sartobind Rapid A can resolve these bottlenecks and innovate the process. 【Seminar Overview】 ▪ Date: January 26, 2023 (Thursday) from 3:00 PM (approximately 40 minutes) ▪ Method: Webinar recorded broadcast [Japanese subtitles, free] If you are unable to participate on the day, please register first. Later, we will send you the URL for the recorded video and related product materials for download. *We apologize, but participation from other companies in the same industry and email addresses not associated with your organization is not permitted. Thank you for your understanding.

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. Freezing, storage, transportation, and thawing are important processes in the manufacturing of biopharmaceuticals. By utilizing the latest single-use technologies, we can implement freezing, thawing, and transportation processes in a robust, safe, and scalable manner. In this first webinar of 2023, we will introduce Sartorius's solution "Celsius" and its features. [Seminar Overview] ▪ Date: January 24, 2023 (Tuesday) from 3:00 PM (approximately 40 minutes) ▪ Method: Webinar recorded broadcast [Japanese, free of charge] *We sincerely apologize, but participation from companies in the same industry and email addresses other than those of your organization is not permitted. Thank you for your understanding.

Registration for this webinar has closed. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. Data has long been considered one of the most important assets for companies, but there are many challenges such as a shortage of digital talent, lack of collaboration within the company, and the speed of decision-making. At Sartorius, we provide "SIMCA" as software that can be used even by those who are not data analysis experts, enabling data visualization and rapid modeling to support enhanced decision-making and data sharing. 【Seminar Overview】 ▪ Date: December 8 (Thursday) from 3:00 PM (approximately 50 minutes) ▪ Method: Webinar recorded broadcast [Japanese, Free] *We sincerely apologize, but we ask that participants from other companies in the same industry, as well as those using email addresses not associated with their organization, refrain from participating. Thank you for your understanding.

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. There is a growing need to obtain CHO cell lines with high expression levels in as short a time as possible for the development and manufacturing of protein drugs such as antibody therapeutics. Sartorius' Cellca cell line development service has developed over 140 CHO cell lines to date, which are used for commercial or clinical trial manufacturing. In this webinar, we will introduce the technical background, service formats (contract and licensing), as well as the characterization tests and safety tests for antibody drugs, protein drugs, and various cells (gene and cell therapy, vaccines, etc.). *We sincerely apologize, but participation from email addresses other than those of your company or organization is not permitted. Thank you for your understanding.

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. In the complex and variable field of biopharmaceutical development, screening for the optimal culture medium requires significant time and effort. The newly launched Sartorius media for CHO and HEK cells that we will introduce supports consistent production from research to manufacturing, with known chemical composition and free from animal-derived components. Additionally, it consists of multiple types of media and feeds, allowing you to select the optimal combination tailored to individual applications and conditions. In this seminar, we will provide information on the characteristics and performance of the media, as well as samples. *We apologize, but participation from email addresses other than those of your company or organization is not permitted. Thank you for your understanding.

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. The development of therapeutics using viral vectors is showing strong activity, with over 30% market growth expected in the next decade. The targets for treatment are diverse, but identifying critical process parameters through process development has become an urgent issue. As the first of two webinars, we will introduce the Ambr series, a representative of process development systems in upstream processes, as well as single-use bag bioreactors up to 2000L for large-scale manufacturing, including examples of associated PAT products. *We sincerely apologize, but participation from email addresses other than those of your company or organization is not permitted. Thank you for your understanding.

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. AAV-based gene therapy is widely accepted and recognized in the biopharmaceutical industry. However, there are still challenges to address in order to manufacture affordable and safe AAV-based products with robust purification processes that are easy to scale up in downstream process development. In this webinar, we will explain how Sartorius can assist you in developing scalable and robust downstream purification processes for AAV using the Monolith provided by Sartorius. AAV Webinar Series 1 is here: https://srtrs.info/ios9v *We apologize, but participation from companies in the same industry and from email addresses other than those of your organization is not permitted. Thank you for your understanding.

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. Since 2020, Sartorius has been continuously working towards process enhancement, and in February, we introduced two bioreactors using single-use bags as the completed form of the enhanced upstream process. We will present the full details of the bioreactor system that meets the needs of commercial production and automation, along with case studies, in this webinar. Related site: https://srtrs.info/r/d7yvo

The reception here has ended. Thank you for your registration. A must-see for those looking for solutions to the complex process development of gene therapy! The field of gene therapy has been receiving increasing attention in recent years, but its long and complex processes involve many considerations, requiring significant time and effort for optimization. At JAACT2022, our specialists will introduce solutions focused on process development using HEK293 cells. In the technical seminar at the venue, we will propose the latest technologies and solutions, including new products. Additionally, at our booth, we will showcase Sartorius's new products (HEK293 media sample kit | Ambr 250 perfusion) and hold demonstrations (MODDE | SIMCA). Technical Seminar Information Title: Challenges in New Modalities by Sartorius Date and Time: July 26 (Wednesday) 15:10 - 15:35 [Main Learning Content] ▪ Case study using microreactor systems (Ambr) ▪ Tools that can be used for scale-up ▪ HEK293 cell culture media system

Registration for this webinar has ended. Thank you for signing up. Sartorius will participate in the co-hosted seminar, "EthanCell Online Forum Technology Presentation Session - CPC Edition: Learning from CPC-related Companies about Various Products and Services for CPC Operations." This seminar aims to provide participants with the opportunity to learn about services and products suitable for each individual through seminars from companies in various fields related to CPC, contributing to the revitalization of regenerative medicine and research. Our company will introduce our media products used for cell culture under the title "Sartorius Media Supporting Robust and Consistent Cell Culture" starting at 14:25.

Participation in this webinar has ended. Those who wish to view it on demand can register through the details and application link. In this webinar, Marion Monstier and Sebastien Chaussin, product managers for freeze-thaw technology, will explain in detail the advantages of single-use containers compared to traditional bottles. They will also clarify important parameters to consider when validating such systems in actual processes. *Additional sessions will be held at times accommodating all time zones. We encourage you to participate and share your feedback. For those who could not attend on the day, a link to the on-demand archive will be sent to registered participants. [Main Learning Points] ▪ Advantages of single-use solutions over bottles ▪ Characteristics of single-use containers that can adapt to existing infrastructure at minimal cost ▪ Confirmation of parameters to consider when selecting single-use containers for freeze-thaw applications

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. During the COVID-19 pandemic, mRNA-based vaccines have been widely recognized by the biopharmaceutical industry and regulatory authorities. However, in downstream process development, there are challenges to address in order to manufacture affordable and safe mRNA-based vaccines using scalable and robust purification processes. We aim to introduce solutions that can be provided using our CIM monolith and develop a scalable and robust downstream purification process from pDNA to mRNA. ▪ Method of holding: Webinar recorded broadcast [in Japanese, free of charge] *We sincerely apologize, but participation from individuals using email addresses other than those from your company or organization is not permitted. Thank you for your understanding.

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. Cellular immunotherapy has scientifically proven the efficacy of CAR-T cells in the treatment of blood cancers, and development is progressing globally. This has heightened interest in the scientific and medical communities and serves as a driving force to develop more effective and cost-efficient cellular immunotherapies. Therefore, the development of high-quality auxiliary materials such as culture media for cultivating these immune cells is crucial. To meet such needs, our company has developed the serum-free 4Cell Nutri-T Medium. Method of delivery: Webinar recorded broadcast (with Japanese subtitles, free of charge) *We sincerely apologize, but participation from email addresses other than those of your company or organization is not permitted. Thank you for your understanding.

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. We will provide information primarily about Sartorius' cross-flow product lineup and its features, as well as explain the single-use hardware that Sartorius has recently started to release. Additionally, we will present the full details of the TFF (Tangential Flow Filtration) hollow fiber modules that we began handling last year. Finally, we will explain how these products are integrated into the processes of the recently highlighted new modalities, such as mRNA and AAV. Related site: https://srtrs.info/r/fmc1u *We sincerely apologize, but we ask that individuals from competing companies or those using email addresses other than those of their affiliated organizations refrain from participating. Thank you for your understanding.

Registration for this webinar has closed. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. Cryopreservation technology is becoming an increasingly essential process in the management and storage of cells, viruses, and protein products during the pharmaceutical manufacturing process. Additionally, cryopreservation technology is widely used for transportation to connect manufacturing plants that are expanding globally. Recently, the necessity for ultra-low temperature transportation and storage of Covid-19 mRNA vaccines has brought attention to cryopreservation technology. Therefore, this webinar will focus on "Considerations for Freezing Processes Using Single-Use Technology." *We apologize, but participation using email addresses other than those from your company or organization is not permitted. Thank you for your understanding.

Participation in this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. In recent years, the rapid spread of mRNA vaccines has suddenly drawn attention to this field, but it seems that a standardized platform has yet to be established. In this webinar, we will particularly address two key points—IVT and purification—through our company's new solution-based approach. 【Main Learning Content】 ▪ Current status and challenges of mRNA pharmaceutical manufacturing processes ▪ Revolutionary purification column (Monolith) ▪ Diverse process development approaches *We kindly ask that inquiries be made using email addresses from your company or organization, as we regretfully cannot accommodate inquiries from other email addresses. Thank you for your understanding.

Participation in this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. In the current era of the new normal, many companies are required to respond to changes, and particularly in the manufacturing sector, we believe that there is a strong effort towards further labor-saving and productivity improvement. Design of Experiments (DOE) has long been used as an effective means for optimal parameter design and creating effective experimental plans. Our company recognizes the increasing importance of DOE, which is why we have chosen it as the theme for this session. In this webinar, we will introduce the basics of DOE, its main experimental objectives, as well as model construction using MODDE and the interpretation of analysis results.

Participation in this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. Since last year, Sartorius has been presenting various proposals and suitable solutions for the challenges of "enhancing processes." In this first webinar of 2022, we will delve deeper than last year's trilogy and discuss several examples regarding cost and equipment considerations. The focus will particularly be on how to manage media that significantly impacts costs and how to design equipment. Please note that this webinar will be presented as the Japanese version of the overseas webinar "Overcoming Facility Constraints Posed by Process Intensification." ▪ Method of holding: Webinar recorded broadcast [Japanese, Free]

Participation in this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. To effectively control the cultivation process and achieve your goals, a compass is necessary. The corresponding technology is process analysis technology, and our latest technique combines Raman spectroscopy analysis. By comparing it with the cultivation models obtained so far, we will be able to predict parameters that could not be analyzed with previous standalone analyzers and move forward. Additionally, the second part of the third session will include content on scaling the cultivation process as a conclusion to the process enhancement campaign. (We plan to have a Q&A session at the end.) [Learnable Elements] ▪ Process analysis technology ▪ Methods for controlling cultivation using Raman spectroscopy ▪ Scale-up [Method of Holding] Live broadcast [Japanese, Free] We will have a Q&A session at the end. *Special novelty gifts will be sent to those who participate in all three sessions on the same day.

Participation in this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. The success or failure of the cultivation process significantly contributes to subsequent productivity, quality, and yield, even within the overall enhanced process. Therefore, the role of process development and optimization for cultivation is positioned as extremely important, and it is necessary to implement these approaches in conjunction with production bioreactors. As the number of considerations increases, there is a demand for cost and labor reduction, and our Amber System is the solution to achieve this. Since 2020, our model capable of perfusion cultivation has received positive feedback, and in the second installment, we will thoroughly convey this feature and its advantages. [Learnable Elements] - Evolved approaches to process development - Advantages of parallel implementation in multi-channel setups [Method of Hosting] Webinar recorded broadcast [Japanese, Free] *Special novelty items will be sent from our company to those who participated in all sessions from the first to the third on the same day.

Participation in this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. In recent years, the manufacturing processes of biopharmaceuticals have been shifting from large-scale equipment structures to enhancing individual processes to increase overall production volume. The core technology continues to heavily utilize single-use systems, and various approaches are available in both upstream and downstream processes to meet the goals of drug manufacturing. We will convey how to enhance your individual processes, including approaches, solutions, and ideal states, and will delve into specific topics in subsequent sessions. [Learnable Elements] - Approaches to process enhancement - Single-use bag bioreactors - Continuous chromatography technology [Method of Delivery] Recorded broadcast [in Japanese, free of charge] *Novelty items will be sent from our company to those who participated continuously from the first to the third session on the same day.

Participation in this webinar has ended. Those who wish to view it on demand can register for details and access it after registration. The mRNA vaccine plays a crucial role in combating SARS-CoV-2, and the necessity to produce mRNA has never been greater due to the ongoing development of treatments for various indications. In Part 2, the product manager and product specialist of the BioSMB system will explain how multi-column chromatography is superior to batch chromatography and how it can increase throughput by up to six times. They will also introduce traditional batch processes and demonstrate how BioSMB can be easily integrated into existing processes without compromising purification performance, throughput, or quality. [Topics] ▪ How batch chromatography limits throughput and increases resin costs ▪ How to improve throughput with less resin using BioSMB's multi-column cycling ▪ An analysis of how increased throughput reduces time to scale-up and the facility footprint.

Registration for this webinar has ended. Those who wish to view it on demand can register through the details and application section. In this webinar, we will explain the main features of the Amber system that correspond to various stages of clone selection under perfusion mimic conditions and complete perfusion conditions, as well as media and feed screening, and optimization of process parameters in small-scale bioreactors. [Topics] - Introduction of high-throughput capabilities for upstream intensification in various modes of Amber: perfusion mimic, ATF, TFF - Amber user case studies: showcasing performance in high-throughput enhanced process development - Discussion of a modular concept for enhanced seed trains utilizing perfusion and decision-making based on specific needs - Evaluation of time and cost advantages of modular seed trains based on predetermined process types Even if you cannot attend the live webinar, a link to the on-demand archive will be sent to those who registered.

Participation in this webinar has ended. Those who wish to view it on demand can register through the details and application section. mRNA vaccines play a crucial role in combating SARS-CoV-2, and the need to produce mRNA has never been greater due to the ongoing development of treatments for various indications. In this three-part webinar series, Sartorius experts will explain how improvements in processes, analytics, and tools are key to meeting demand. Part 1 will explore the processes, analytics, and tools needed to meet the high demand for mRNA, starting with the production of pDNA. We will introduce methods to achieve high yields of pDNA by ensuring the quality and purity of raw materials and optimizing the manufacturing process. [Topics] ▪ Examination of strategies to minimize contamination from product-derived impurities in IVT reactions ▪ Introduction of ready-to-use solutions for scalable pDNA chromatography purification ▪ Verification of the actual effectiveness of the HiP2 Plasmid Process Pack for purifying linearized pDNA

Participation in this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. In this webinar, we will introduce the overall picture of the solutions proposed by Sartorius, from process development to commercial manufacturing of AAV vector production. In the latter part, we will particularly focus on the purification aspect, which is considered a bottleneck in AAV vector manufacturing, and introduce chromatography products and their applications. 【Main Learning Content】 ▪Overview of AAV vector manufacturing ▪AAV vector manufacturing solutions proposed by Sartorius ▪Purification of AAV vectors using chromatography 【Recommended for】 ▪Those interested in gene and cell therapy technologies ▪Those involved in the research and development or manufacturing of gene therapies ▪Those struggling with the purification of AAV vectors 【Method of Delivery】 Webinar recorded broadcast 【In Japanese, Free】 *To participate in the webinar, you will need to install the Zoom app. Instructions for installation will be included in the confirmation email after registration.

Registration for this webinar has ended. If you would like to access the on-demand version, please register through the details and application link provided. In this webinar, you will learn about leveling up the process development of T cells. <Main Content> - Promotion of media screening and identification and optimization of CPP (Critical Process Parameters) - Profiling of CAR-T cells and clustering of donors - Reduction of development time and COGs *Even if you cannot attend the live broadcast, those who register will receive a link to the on-demand archive. Starts on July 30 (Friday) at 00:00 (International time: July 29 (Thursday) 11:00 AM EDT | 8:00 AM PDT | 5 PM CEST) Related website https://bit.ly/2V9rh9u

Participation in this webinar has ended. Those who wish to view it on demand can register through the details and application section. In this series, we will provide the best information to help with various best practices, important considerations, and process enhancement strategies for new and existing facilities. **Media Management to Promote Process Advancement** In this webinar, Stuart Tindal, PhD, Product Manager of Flexact Modular, and Myriam Lavie, Senior Product Manager of Fluid Management Technologies, will explain why media management is an important consideration for companies implementing process enhancements upstream. **Main Content** - Learn how to model and prepare various media configurations - Discuss scheduling and usage of media management equipment - Understand how to mitigate risks when facing quality issues or process failures **Related Website** https://bit.ly/3hOaIb1