ティー・エイ・インスツルメント・ジャパン （TAInstruments） Official site

Step into the utilization of thermal analysis devices. Numerous measurement examples of DSC included. Online seminar held.

【Other Published Content (Excerpt)】 ■ Isothermal Titration Calorimeter "Affinity ITC" Measurement Examples: Evaluation of binding constants between enzymes and inhibitors, evaluation of enzyme kinetics, and the effects of inhibitors. ■ Microcalorimeter for Biomacromolecules "Nano DSC" Measurement Examples: Comparison between capillary cells using Nano DSC and conventional coil-type cells. ■ Isothermal Calorimetry Device "TAM" Measurement Examples: Evaluation of the efficacy of anticancer drugs through metabolic measurements of tumor cells. *For details on published content and online seminar summaries, please refer to "PDF Download." Feel free to contact us with any inquiries.

This is an introduction to protein analysis cases and related equipment by analysis specialists. This time, we will cover three devices: ITC, TAM, and NanoDSC!

At TA Instruments, we handle a wide range of equipment including "thermal analysis instruments," "viscoelastic measurement devices and rheometers," "microcalorimeters (for biological and medical fields)," and "fatigue testing machines." This time, we will introduce three types of devices that are particularly suitable for evaluation in the fields of biology, bio, and pharmaceuticals, known as "microcalorimeters." 【Agenda】 P3~ Introduction to ITC (Isothermal Titration Calorimeter) Evaluation of binding constants of enzymes and inhibitors Kinetic evaluation of enzyme reactions and the effects of inhibitors P6~ Introduction to NanoDSC (Differential Scanning Calorimeter) Case studies on the stability and denaturation behavior of proteins Evaluation of the dependence of protein denaturation temperature on Zn2+ ion concentration P9~ Introduction to TAM (Isothermal Calorimeter) Evaluation of the efficacy of anticancer drugs through metabolic measurements of tumor cells

How about one for the lab? Introducing the Discovery DSC series, the world's most outstanding and highly versatile differential scanning calorimeter.

Features and Benefits - Patented new Fusion CellTM technology Unmatched performance in baseline flatness, sensitivity, resolution, reproducibility, and reliability - Innovative "app format" touchscreen Enhanced operability with easy One-Touch-AwayTM functionality, making data acquisition easier than ever - Reliable linear autosampler with 54 programmable tray positions 24-hour operation, flexible measurement programming, and automatic calibration routines available - Modulated DSC (MDSC) Most efficiently separates complex thermal events, improving data interpretation reliability - Wide temperature range with electric cooling options Eliminates the running costs of liquid nitrogen and enables long-term continuous operation using an autosampler - Tzero press and pan Allows for quick, simple, and highly reproducible sample preparation

Provides high reliability! An excellent tool for measuring a wide range of molecular interactions.

■Measurement range: -10°C to 130°C ■Cell capacity: Standard capacity (1.0 mL), low capacity (190 µL) ■Stirring speed: 10 to 1000 rpm ■Temperature control: Solid-state active heating and cooling ■Auto-sampler: 96-well, temperature controlled ■Software: ITCRun, NanoAnalyze ■Cleaning function: Automatic cleaning, user-selectable system cleaning routine

A differential scanning calorimeter specialized for studying biological samples. It offers the highest sensitivity and excellent operability.

<Specifications> Short-term noise: 0.015 μW Baseline stability: ±0.028 μW Response time: 5 seconds Operating temperature range: -10 to 130 ℃ or 160 ℃ (high-temperature option required) Temperature scan speed: up to 2 ℃/min Pressure perturbation: 6 atm built-in Cell volume: 300 μL Geometry: fixed capillary Cell material: platinum Thermal measurement type: input compensation

For the evaluation of reactions of various substances.

The microcalorimeter does not destroy or invade the sample at all. It requires almost no prior adjustment of the sample, and the analysis is not limited by the physical state of the sample. It can be examined in solid, liquid, or gas form. Additionally, there is no requirement for the sample to possess specific characteristics, as is the case with measurements like FTIR, UV-Vis, or NMR. It directly and continuously measures the process of the subject. Unlike other analytical methods that provide fragmented data, it continuously provides real-time data as the process progresses.

World leader in thermal analysis, calorimetry, and rheology / Comprehensive catalog of TA Instruments.

Tokyo Lab / Nishi Gotanda, Shinagawa-ku, Tokyo Osaka Lab / Nishi Nakajima, Yodogawa-ku, Osaka We have a lab equipped with thermal analysis, calorimetry, and viscoelasticity measurement, among others. We are always ready to accept samples for measurement, so please feel free to contact us.

This is the lecture material posted on YouTube ~DSC Basic Edition 1~. It is available for free download, so please feel free to make use of it.

We would like to introduce a YouTube course on DSC from TA Instruments, the world leader in thermal analysis. What can you learn from DSC? How should you analyze the graphs? The graphs are different between the first and second measurements... why is that? We are offering a groundbreaking tool to solve these questions for free. Lecture materials are also available for free on the Ipros site, so please make use of them.

This is the lecture material posted on YouTube ~Rheology: Basic Edition 1~. It is available for free download, so please feel free to make use of it.

We would like to introduce a YouTube course on rheology from TA Instruments, the world leader in viscoelasticity. What is rheology, anyway? Even if you mention viscoelasticity, it doesn't really resonate with me... There are too many measurement modes; which one should I use... Can someone help me? We are offering a groundbreaking tool to solve these questions for free. We are also providing lecture materials for free on the Ipros site, so please make use of them.

This is an introduction to analysis cases and related devices for bio research by analysis specialists. This time, we will cover three devices: ITC, TAM, and NanoDSC!

At TA Instruments, we handle a wide range of equipment including "thermal analysis instruments," "viscoelastic measurement devices and rheometers," "microcalorimeters (for biological and medical fields)," and "fatigue testing machines." This time, we will introduce three types of devices known as "microcalorimeters," which are highly suitable for evaluation in the fields of biology, biotechnology, and pharmaceuticals. ◆ Isothermal Titration Calorimeter (ITC) The isothermal titration calorimeter (ITC) is a device that detects the heat changes associated with titration at a constant temperature, primarily used for analyzing molecular interactions. It measures the minute heat changes that occur when molecules bind to each other, allowing for the determination of binding ratios (n), binding constants (Ka), and changes in enthalpy of binding (ΔH) from the resulting titration curves. ◆ Isothermal Calorimeter (TAM) The thermal analysis measurement device (TAM) is a highly sensitive, stable, and flexible microcalorimeter system that can directly measure universal thermal signals, enabling quantitative thermodynamic and kinetic observations of any process. ◆ Biological Microcalorimeter (NanoDSC) The biological microcalorimeter (nano DSC) is the most widely used thermal analysis instrument for evaluating the physical properties of a broad range of materials, including polymers, pharmaceuticals, food, biological substances, organic compounds, inorganic compounds, and composite materials.

This is an introduction to a protein analysis case study by a specialist in analysis. This time, we evaluated the changes in denaturation temperature behavior with the addition of Zn2+ using NanoDSC.

At TA Instruments, we handle a wide range of equipment including "thermal analysis instruments," "viscoelastic measurement devices and rheometers," "microcalorimeters (for biological and medical fields)," and "fatigue testing machines." This time, we will introduce three types of microcalorimeters, which are very suitable for evaluation in the fields of biology, bio, and pharmaceuticals. ◆Microcalorimeter for Biological Use (NanoDSC) The microcalorimeter for biological use (nano DSC) is the most widely used thermal analysis instrument for the physical property evaluation of a broad range of materials including polymers, pharmaceuticals, food, biological substances, organic compounds, inorganic compounds, and composite materials.

This is an introduction to a protein analysis case study by a specialist in analysis. This time, we evaluated the substrate degradation rate and the effects of inhibitors using ITC.

At TA Instruments, we handle a wide range of equipment, including "thermal analysis instruments," "viscoelastic measurement devices and rheometers," "microcalorimeters (for the life sciences and medical fields)," and "fatigue testing machines." This time, we will introduce three types of equipment known as "microcalorimeters," which are highly suitable for evaluation in the life sciences, biotechnology, and pharmaceutical fields. ◆ Isothermal Titration Calorimeter (ITC) The isothermal titration calorimeter (ITC) is a device that detects the heat changes associated with titration at a constant temperature, primarily used for analyzing molecular interactions. It measures the minute heat changes that occur when molecules bind to each other, allowing for the determination of binding ratios (n), binding constants (Ka), and changes in enthalpy of binding (ΔH) from the resulting titration curves.

Virus Research Case Study: Characterization of Viruses - Evaluation of Structure and Binding Properties Using Calorimetry -

<Nano DSC> The Nano-DSC from TA Instruments is crucial for elucidating the thermodynamic profile of viral structures, leading to an understanding of the stability of viral components and reliable characterization and identification of viral strains. <Affinity ITC> The toxicity of a virus depends on its ability to specifically bind to and infect target cells. The Affinity-ITC from TA Instruments has been demonstrated to be a powerful assay technique that can be used to thermodynamically characterize these molecular interactions. For inquiries regarding equipment specifications and measurements, please contact infojapan@tainstruments.com. Alternatively, you can fill out and submit the contact form on our website. https://reg34.smp.ne.jp/regist/is?SMPFORM=mis-ncsi-657ae9d8d4a794e455fa0febda47cff9

This is an introduction to case studies related to cells by a specialist in analysis. This time, we will present measurement examples using thermal analysis equipment that is useful for evaluations involving cells.

This time, TA Instruments introduces a device called "TAM," which is an isothermal calorimeter. In this article, we will present a case study related to cell culture, specifically evaluating the efficacy of anticancer drugs through the measurement of tumor cell metabolism. ◆ Evaluation of Anticancer Drug Efficacy through Tumor Cell Metabolism Measurement Heat flow (the change in heat per unit time) shows higher values as the metabolism of the cells becomes more active. As the concentration of the anticancer drug increases, the heat flow values over a long period decrease, indicating that the metabolism of the tumor cells is declining. From the measurement results, a dose-response curve can also be created, and the TAM can be used as a rapid bioassay method.

This is an introduction to case studies of pharmaceutical analysis by a specialist in analysis. This time, we will look at the pharmacokinetics of suppositories and the viscoelastic measurement of hair wax.

TA Instruments handles a viscoelastic measurement device called a "rheometer." In this article, we will introduce examples of viscoelastic measurements of familiar pharmaceutical cosmetics, specifically suppositories and hair wax, along with an easy-to-understand model of the measurement process. ◆ Softening Behavior of Suppositories in the Body For suppositories that are injected and used within the body, the viscoelasticity at storage temperature and body temperature greatly affects product performance. Therefore, we conducted temperature-dependent viscoelasticity measurements on two types of suppository samples. ◆ Application Feel of Hair Wax and Creep Recovery Test It is common to see a wide variety of hair waxes displayed, catering to different hair types and desired hairstyles. When you pick them up, each has a different feel, suggesting variations in viscoelasticity. Using a rheometer, we can quantitatively evaluate basic viscoelastic indicators such as elasticity and viscosity. Additionally, as introduced below, we can assess the stretchability and holding power of hair wax through a measurement mode that simulates the application process on hair (creep recovery test).

This is an introduction to medical-related analysis cases by a specialist in analysis. This time, we will present measurement cases of mechanical properties and fatigue tests that are useful for evaluating the pericardium.

This time, TA Instruments introduces the "ElectroForce Series," a fatigue testing machine. In this article, we will present a case study on the evaluation of the mechanical properties of pericardium using a planar biaxial testing machine, related to cell culture and medical applications. ❖ Evaluation of the Mechanical Properties of Pericardium Using a Planar Biaxial Testing Machine The pericardial tissue was attached to the planar biaxial testing machine, and equal displacements were applied to each axis to measure the load. It was found that the load at a larger displacement was greater on the 90° axis than on the 0° axis, indicating that the mechanical properties of the measured pericardial tissue exhibit anisotropy. ■ Load Capacity: 200N, 400N ■ Motor: ElectroForce Linear Motor ■ Displacement Range: 13mm ■ Control Functions: Load, Displacement, Strain Control ■ Mounting Options: Horizontal or Vertical ■ Accessories: Physiological Saline Bath, Multi-Axis Load Options ■ Test Profiles: Single push-to-failure, pull-to-failure, repetitive loading, creep/stress relaxation measurement

Using PLA beverage cups as measurement samples, thermal and mechanical properties were investigated utilizing thermal analysis techniques such as temperature-modulated DSC and DMA!

◆Discovery DSC Differential Scanning Calorimeter Measures temperature transitions in materials along with associated thermal temperature and heat flow. Common applications include investigation, selection, comparison, and final performance evaluation of materials in research, quality control, and manufacturing. Characteristics measured by TA Instruments' DSC technology include glass transition, "cold" crystallization, phase changes, melting, crystallization, product stability, curing/cure reaction rates, and oxidation stability. ◆Discovery DMA Dynamic Mechanical Analyzer Measures the mechanical properties of materials as a function of time, temperature, and frequency. In addition to basic material properties, DMA quantifies finishing characteristics and reflects the significant contributions of processing to final performance. DMA is commonly used to measure glass transition temperature and secondary transitions, orientation induced by processing, cold crystallization, curing optimization, and filler effects in composites. DMA not only provides an accurate measure of material stiffness (modulus) but also offers insights into other important mechanical properties such as damping, creep, and stress relaxation.

This is an introduction to a case study of insulation material analysis by a specialist in analysis. This time, we will present a measurement case using a thermal conductivity measurement device.

This time, TA Instruments introduces a thermal conductivity measurement device called "FOX." In this article, we will present a case study on the anisotropic evaluation of the R-value (thermal resistance value) of insulation boards as an analysis related to insulation materials. ◆ Anisotropic Evaluation of the R-value (Thermal Resistance Value) of Insulation Boards Insulation boards are materials used in various places, such as the walls of houses. In fact, the insulation effect of these boards changes when the board is laid horizontally compared to when it is stood vertically. Our thermal conductivity measurement device, FOX, shows the thermal resistance values of the insulation board when laid flat and when stood upright.

Evaluation of the generation process and characteristics of biofuels using a modular thermal analysis measurement device (TAM).

It is equipped with excellent features that provide reliable and meaningful results for the evaluation and optimization of biofuel properties. In temperature scan (DSC) mode, the wax appearance temperature (WAT) is clearly visualized, and in isothermal mode, the reaction rate of catalytic reactions in the fuel generation process can be observed over time. Among analytical instruments and calorimetry devices, the TAM can evaluate a variety of products including liquids, solids, crystals, polymers, fuels, foods, and batteries. 【Features】 - Highly responsive temperature control, adjustable in the range of 4 to 150 ℃ - Accurate and stable heat flow measurements even in long-term experiments - Up to four calorimeter positions can accommodate a maximum of four calorimeters - Calorimeters are available in various configurations such as size and sensitivity - Up to eight independent accessories can be controlled - New voltage I/O module for independent probe/source interface 【Specifications】 [Thermostat] - Heat medium: Oil - Number of calorimeters: 4 - Temperature range: 4 to 150 ℃ - Accuracy: < ± 0.1 ℃ - Long-term stability: < ± 100 μ ℃/24h - Scan speed: ≤ ± 2 ℃/h