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[Analysis Case] Evaluation of Composition Distribution in Bone Cross-Sections

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[Analysis Case] Evaluation of Composition Distribution in Bone Cross-Sections

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Visualization of the composition distribution of mouse tibial cross-sections using TOF-SIMS.

To evaluate the component distribution in mouse tibia, we prepared tibial sections and conducted imaging analysis using TOF-SIMS. The distribution of components derived from mice, such as K, Ca, calcium phosphate, and phospholipids, was confirmed. Since TOF-SIMS identifies components based on the mass of molecular ions, it does not require labeling substances like fluorescent materials, allowing for distribution evaluation without the influence of labeling agents. This technique can be applied to drug dynamics analysis and research on Drug Delivery Systems (DDS), enabling imaging of drug distribution within organs.

Related Link - https://www.mst.or.jp/casestudy/tabid/1318/pdid/18…

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[Analysis Case] Evaluation of Composition Distribution in Bone Cross-Section_C0422

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