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[Analysis Case] Evaluation of Transdermal Absorption of Indomethacin in Rat Skin

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[Analysis Case] Evaluation of Transdermal Absorption of Indomethacin in Rat Skin

Visualization of the distribution of active ingredients in biological tissues using TOF-SIMS.

TOF-SIMS identifies components based on the mass of molecular ions, eliminating the need for labels such as fluorescent substances, allowing for imaging evaluations without their influence. Additionally, by performing cross-sectional imaging, it is possible to assess distribution in the depth direction. In this study, a gel formulation of indomethacin was applied to rat skin for 2 hours, and the distribution of the permeated active ingredient was visualized. As a result, indomethacin was found to be highly concentrated at approximately 5μm on the stratum corneum surface, and the depth profile analysis showed that it was gradually permeating.

Related Link - https://www.mst.or.jp/casestudy/tabid/1318/pdid/27…

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Analysis of pharmaceuticals and cosmetics.

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[Analysis Case] Evaluation of Transdermal Absorption of Indomethacin in Rat Skin_C0428

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