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[Analysis Case] Evaluation of Component Distribution in Skin Cross-Section

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[Analysis Case] Evaluation of Component Distribution in Skin Cross-Section

It is possible to visualize molecular information of organic and inorganic substances.

We created skin tissue samples and evaluated the distribution of biogenic components in freeze-dried samples using TOF-SIMS. Since TOF-SIMS identifies components based on the mass of molecular ions, it does not require labels such as fluorescent substances, allowing for the evaluation of distribution without the influence of labeled materials. The mapping results confirmed that arginine, a natural moisturizing factor (NMF), and cholesterol, which retains moisture as an intercellular lipid, are localized in the stratum corneum. This method is also effective for assessing the permeation state during drug application.

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Measurement method: TOF-SIMS Product fields: Cosmetics, pharmaceuticals, daily necessities, biotechnology Analysis purpose: Composition distribution evaluation

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Analysis of cosmetics, pharmaceuticals, daily necessities, and biotechnology.

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